Omega3 may be anabolic at higher dosages

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There is now converging evidence in animals and humans that omega-3 fatty acids are at the least anti-catabolic and, likely, anabolic. • They seem to do this by shifting the balance away from breakdown and more towards muscle building, particularly in the context of anabolic resistance. • Animal studies show omega-3 fatty acids augment muscle development: • Steers fed omega-3s showed improved amino acid efficiency and activated pathways involved in muscle growth. Similarly, pigs given a high omega-3 diet exhibited larger muscles and markers of improved amino acid absorption and use. • But more importantly, we have human evidence: • • In one study, young women taking 5 grams of omega-3s per day cut their muscle loss almost in half and increased muscle protein synthesis after two weeks of leg immobilization. • • In another study, older adults consuming 3.36 grams of omega-3s daily for two months had an increase in muscle protein synthesis in the presence of amino acids and insulin. • • Yet another study found that healthy older adults taking 4 grams of omega-3s daily for half a year increased various measures of muscle size and strength. • • Still another study, older adults who consumed 4 grams of krill oil daily for six months improved knee strength, grip strength, thigh muscle thickness, and measures of muscle nerve response. • There are still open questions. For example, a consistent theme is that many of the studies are high dose at 4 and 5 grams per day - does that imply that these effects in muscle only happen at high dosages? • Another question we might ask is, in what context is omega-3 more anabolic - for example, in old age? During immobilization? When protein intake is sub-optimal for muscle building? • (It often is for many of us.) • Listen to my recent podcast guest Dr. Chris McGlory for more discussion of this fascinating new emerging field. • Show notes and transcript for this episode here: • https://www.foundmyfitness.com/episod... • #omega3 #muscle #fitness

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