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DielsAlder reaction
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The Diels–Alder Reaction is the [4 + 2] cyclization of a diene and a dienophile to generate a cyclohexene derivative. • Reaction mechanism: • A concerted, pericyclic reaction that generates two new σ-bonds through a cyclic transition state where the HOMO of the electron-rich component interacts with the LUMO of the electron-poor one. Usually, the diene component is electron-rich and the dienophile is electron-poor. But sometimes the diene is electron-poor, by the presence of an electron-withdrawing group, and the dienophile electron-rich, by the presence of an electron-donating group. • References: • NROChemistry: https://nrochemistry.com/diels-alder-... • Example #1: Angew. Chem. Int. Ed. 2021, 60, 21267. https://doi.org/10.1002/anie.202107954 • Example #2: J. Org. Chem. 2021, 86, 3605. https://doi.org/10.1021/acs.joc.0c02966
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