How E2 Elimination Reactions Work Animation Mechanism amp Orbitals Organic Chemistry

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👀 This video explains E2 eliminations: basics of geometries, orbitals, selectivities... • https://total-synthesis.com/organic-c... • 🧑‍🎓➡️ Free organic chemistry practice problems • / totalsynthesis • 🚀 Thanks to all channel supporters!!! • / totalsynthesis_official • 👉 Follow me on Instagram for updates on random research, chemistry problems and interesting news! • https://total-synthesis.com • 00:00 E2 elimination basics and orbitals • 01:14 Ask yourself these questions • 01:31 Level 1: 2-Bromobutane elimination and stereoselectivity • 02:46 Level 2: Kinetic isotope effects and stereospecificity • 04:35 Level 3: Cyclic substrates and A-values • 06:25 Level 4: Peterson olefination and Brook rearrangement • • The bimolecular elimination (E2 elimination) reaction is a cornerstone of organic chemistry, particularly for synthesis of alkenes. In the E2 mechanism, a base abstracts a proton (H+) from a carbon adjacent to an sp3-hybridized carbon, which is bonded to a leaving group. Simultaneous expulsion of the leaving group, forms a double bond (alkene) - with a concerted mechanism (deprotonation and and leaving group departure occur in a single step). This contrasts with the E1 elimination mechanism, where the leaving group's departure is the rate-determining step and occurs before the deprotonation step. • Some recommended books on organic synthesis: • Clayden, Greeves, Warren; Organic Chemistry (basic organic chemistry knowledge) • Wyatt, Warren; Organic Synthesis: The Disconnection Approach (excellent introduction to retrosynthesis) • Kurti, Czako; Strategic Applications of Named Reactions in Organic Synthesis (extensive toolkit of functional group reactions and applications thereof with common conditions) • Nicolaou; Classics in Total Synthesis 1-3 (the ultimate total synthesis trilogy) • Nicolaou; Molecules That Changed the World (the world's most important molecules and their impact on everyday life) • Carreira, Kvaerno; Classics in Stereoselective Synthesis (compilation of the groundbreaking methods of stereoselective synthesis and application to synthesis of stereochemically complex structures)

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