Proton pump inhibitors Omeprazole pantoprazole and other prazole medications

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http://youtube.com/watch?v=4-SA63VFGDY

Freshman Organic Chemistry (CHEM 125) • The chemical mode of action of omeprazole is expected to be insensitive to its stereochemistry, making clinical trials of the proposed virtues of a chiral switch crucial. Design of the clinical trials is discussed in the context of marketing. Otolaryngologist Dr. Dianne Duffey provides a clinician's perspective on the testing and marketing of pharmaceuticals, on the FDA approval process, on clinical trial system, on off-label uses, and on individual and institutional responsibility for evaluating pharmaceuticals. • 00:00 - Chapter 1. Introduction: The Chemical Properties and Reactivity of Prilosec • 06:58 - Chapter 2. The Economics of Clinical Trials • 19:57 - Chapter 3. Duffey: How Do I Know that the Drug is Effective? • 30:26 - Chapter 4. The Phases of Clinical Trials, Results for Esomeprazole and Omeprazole, and Off-Label Use • 42:01 - Chapter 5. Pharmaceutical Marketing Mentality and Q A • Complete course materials are available at the Open Yale Courses website: http://open.yale.edu/courses • This course was recorded in Fall 2008.

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