Isotretinoin in Dermatology Agent Mechanism of Action Uses Sideeffects

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#isotretinoin #acne #retinoids • Hi. With this video, we will discuss the use of Isotretinoin in Dermatology and be better prepared for treating our patients. This video is directed towards dermatologists and is not at all advisory for non-medical personnel. • Introduction - 01:41 • Pharmacology - 03:24 • Mechanism of Action - 05:35 • Mechanism of Action: Apoptosis - 08:46 • Mechanism of Action: Acne - 11:52 • Uses: Acne - 14:22 • Uses: Seborrhiec Dermatitis - 20:38 • Uses: Rosacea - 21:53 • Uses: Hidradenitis Suppurativa - 23:19 • Uses: Genodermatoses - 24:57 • Uses: HPV - 26:02 • Uses: Skin Cancers - 28:38 • Other uses - 31:17 • Adverse Effects - 32:35 • Teratogenicity - 35:58 • Isotretinoin and Pregnancy - 39:16 • iPLEDGE-REMS - 42:27 • Adverse Effects: Wound Healing - 46:40 • Adverse Effects: Psychiatric - 49:07 • Drug Interactions - 51:06 • Further Reading - 53:18 • End - 53:57 • Good articles on Isotretinoin: • 1. Isotretinoin; Product Insert • 2. Layton A. The use of isotretinoin in acne. Dermatoendocrinol. 2009 May;1(3):162-9. doi: 10.4161/derm.1.3.9364. PMID: 20436884; PMCID: PMC2835909. • 3. Paichitrojjana A, Paichitrojjana A. Oral Isotretinoin and Its Uses in Dermatology: A Review. Drug Des Devel Ther. 2023 Aug 25;17:2573-2591. doi: 10.2147/DDDT.S427530. PMID: 37649956; PMCID: PMC10464604. • 4. Chu S, Michelle L, Ekelem C, Sung CT, Rojek N, Mesinkovska NA. Oral isotretinoin for the treatment of dermatologic conditions other than acne: a systematic review and discussion of future directions. Arch Dermatol Res. 2021 Aug;313(6):391-430. doi: 10.1007/s00403-020-02152-4. Epub 2020 Nov 5. PMID: 33151346. • 5. Brzezinski P, Borowska K, Chiriac A, Smigielski J. Adverse effects of isotretinoin: A large, retrospective review. Dermatol Ther. 2017 Jul;30(4). doi: 10.1111/dth.12483. Epub 2017 Mar 14. PMID: 28295859. • 6. Spring LK, Krakowski AC, Alam M et al. Isotretinoin and Timing of Procedural Interventions: A Systematic Review With Consensus Recommendations. JAMA Dermatol. 2017 Aug 1;153(8):802-809. doi: 10.1001/jamadermatol.2017.2077. PMID: 28658462.

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