HEREDITARY SPHEROCYTOSIS Pathogenesis Clinical Symptoms Treatment

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🩸 Hereditary Spherocytosis: Pathogenesis, Symptoms Treatment Explained • Hereditary Spherocytosis (HS) is a genetic disorder of red blood cell membrane proteins, leading to hemolytic anemia, jaundice, and splenomegaly. But what causes it, and how is it diagnosed and treated? This video provides a high-yield breakdown of HS pathogenesis, clinical symptoms, diagnostic criteria, and treatment, perfect for medical students, USMLE prep, and healthcare professionals. • What You’ll Learn in This Video: • ✔️ Pathogenesis of HS: Defects in spectrin, ankyrin, or band 3 proteins • ✔️ Why do RBCs become spherical? Loss of membrane flexibility splenic destruction • ✔️ Clinical symptoms: Hemolytic anemia, jaundice, splenomegaly, and gallstones • ✔️ Diagnostic tests: Osmotic fragility test, EMA binding test, peripheral blood smear • ✔️ Treatment options: Folic acid, splenectomy, and supportive care • ✔️ High-yield mnemonics USMLE exam pearls • ⏰ Timestamps for Easy Navigation: • 0:00 What is hereditary spherocytosis (Minkowski–Chauffard syndrome) • 1:37 How spherocytes are formed • 4:28 The pathogenesis of hereditary spherocytosis • 10:07 Blood analysis of a patient with Hereditary spherocytosis • 11:35 EMA binding test • 12:57 Osmotic fragility test • https://t.me/foxterRier_med • • #usmle #step1 #step2 #medicine #pathology #physiology #education #medicalschool #pharmacology #biochemistry #highyield #lab

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