Thiazide Diuretics Their Multiple Mechanisms amp Indications

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Hydrochlorothiazide (HCTZ): is a thiazide diuretic that works to inhibit the activity of sodium/chloride resorption in the distal convoluted tubule. As less solute is resorbed, more water is lost to the urine due to the shift in osmotic pressure. The activity of HCTZ (and thiazide diuretics in general) will also decrease Ca2+ excretion by the distal convoluted tubule (calcium sparing diuretic) because normally sodium and calcium compete for resorption. • Read more here: http://www.stepwards.com/?page_id=1671

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