Youtor
Carbamazepine overdose and poisoning
>> YOUR LINK HERE: ___ http://youtube.com/watch?v=6bzJ5PVBlbw
Carbamazepine is a potentially lethal drug in overdose, so it pays to know about it. This short video has a good overview of the toxicology essentials involved. • Please do subscribe and like the video as I do this all for free and getting positive feedback gives me a buzz. • Structurally carbamazepine is similar to imipramine (a tricyclic antidepressant) so an easy way to remember the effects in overdose is to think about TCA overdoses. • In particular carbamazepine has significant anticholinergic/antimuscarinic effects, and these contribute to a number of things including ileus and pharmacobezoar formation. • • References: • https://www.austin.org.au/Assets/File... • Albertson TE, Dawson A, de Latorre F, Hoffman RS, Hollander JE, Jaeger A, et al. TOX-ACLS: toxicologic-oriented advanced cardiac life support. Ann Emerg Med 2001;37(4 Suppl):S78–90 • Brahmi N, Kouraichi N, Thabet H, Amamou M. Influence of activated charcoal on the pharmacokinetics and the clinical features of carbamazepine poisoning. Am J Emerg Med 2006;24(4):440–3 • Dassanayake TL, Jones AL, Michie PT, Carter GL, McElduff P, Stokes BJ, et al. Risk of road traffic accidents in patients discharged following treatment for psychotropic drug overdose: a self-controlled case series study in Australia. CNS Drugs 2012;26(3):269–76. • Dassanayake TL, Michie PT, Jones AL, Mallard T, Whyte IM, Carter GL. Cognitive skills underlying driving in patients discharged following self-poisoning with central nervous system depressant drugs. Traffic Inj Prev 2012;13(5):450–7. • Ghannoum M, Yates C, Galvao TF, Sowinski KM, Vo TH, Coogan A, et al. Extracorporeal treatment for carbamazepine poisoning: systematic review and recommendations from the EXTRIP workgroup. Clin Toxicol (Phila) 2014;52(10):993–1004 • Gunja N, Graudins A. Management of cardiac arrest following poisoning. Emerg Med Australas 2011;23(1):16–22. • Hojer J, Malmlund HO, Berg A. Clinical features in 28 consecutive cases of laboratory confirmed massive poisoning with carbamazepine alone. J Toxicol Clin Toxicol 1993;31(3):449–58 • May TW, Korn-Merker E, Rambeck B. Clinical pharmacokinetics of oxcarbazepine. Clin Pharmacokinet 2003;42(12):1023–42 • Mortensen KE, Munkholm J, Dalhoff KP, Hoegberg LC. Oesophageal obstruction from a pharmacobezoar resulting in death. Basic Clin Pharmacol Toxicol 2017;120(2):213–6. • Spiller HA, Krenzelok EP, Cookson E. Carbamazepine overdose: a prospective study of serum levels and toxicity. J Toxicol Clin Toxicol 1990;28(4):445–58. • Spiller HA, Strauch J, Essing-Spiller SJ, Burns G. Thirteen years of oxcarbazepine exposures reported to US poison centers: 2000 to 2012. Hum Exp Toxicol 2016;35(10):1055–9 • van Opstal JM, Janknegt R, Cilissen J, L’Ortije WH, Nel JE, De Heer F. Severe overdosage with the antiepileptic drug oxcarbazepine. Br J Clin Pharmacol 2004;58(3):329–31. • Wills B, Reynolds P, Chu E, Murphy C, Cumpston K, Stromberg P, et al. Clinical outcomes in newer anticonvulsant overdose: a poison center observational study. J Med Toxicol 2014;10(3):254–60
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