Immune Response Explained TCell Activation











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Every day billions of tiny invaders called pathogens want to make our bodies their new homes. Luckily, we have a powerful army of specialized organs, cells, and tissues that work together to protect us. This is your body's immune system. Within this complex system is type of lymphocyte called a T-cell. This video will introduce you to Helper and Cytotoxic T-cells, and describe the mechanism by which they are activated when encountered by a pathogen. If you wish to know more about this remarkable process, make sure to stay tuned so we can demystify T-cells together! • This video was made by Demystifying Medicine students Navroop • Gosal, Jiayi Mo, Xiuyuan Song and Sara Warsi, in collaboration with the McMaster Demystifying Medicine Program. • Copyright McMaster University 2020 • • References: • Cavanagh, M. (n.d). T cell Activation. British Society for Immunology. Retrieved from https://www.immunology.org/public-inf... • Gaudino, S. J., Kumar, P. (2019). Cross-talk between antigen presenting cells and T cells impacts intestinal homeostasis, bacterial infections, and tumorigenesis. Frontiers in immunology, 10, 360. https://doi.org/10.3389/fimmu.2019.00360 • IQWiG (Institute for Quality and Efficiency in Health Care). (2020, July 30). The innate and adaptive immune systems. Retrieved from https://www.ncbi.nlm.nih.gov/books/NB... • Sauls, R. S., McCausland, C., Taylor, B. N. (2019). Histology, T-Cell Lymphocyte. In StatPearls [Internet]. StatPearls Publishing. • Smith-Garvin, J. E., Koretzky, G. A., Jordan, M. S. (2009). T cell activation. Annual review of immunology, 27, 591-619. DOI: 10.1146/annurev.immunol.021908.132706 • Storey, M., Jordan, S. (2008). An overview of the immune system. Nursing Standard, 23 (15-17):47-56. DOI: 10.7748/ns2008.12.23.15.47.c6738

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