What parents need to know about Duchenne muscular dystrophy

>> YOUR LINK HERE: ___ http://youtube.com/watch?v=7EHdCQn6M4Y

This video explores the most common muscular dystrophy in children called Duchenne muscular dystrophy (DMD), a genetic disorder. DMD is explained through signs and symptoms, pathogenesis, diagnosis and disease progression. Studies were used to explain the benefits of exercise as well as treatment with Deflazacort. • This video was made by Demystifying Medicine students Lamisha Khandaker, Kunal Mehta, Michelle Rong, and Dhruvika Joshi. • Copyright McMaster University 2018 • If you'd like to learn more about DMD and how you can help, please visit: • https://www.mda.org/disease/duchenne-... • Here are the 2 studies mentioned in the video: • Study on Delflazacort: • Griggs, R. C., Miller, J. P., Greenberg, C. R., Fehlings, D. L., Pestronk, A., Mendell, J. R., . . . Meyer, J. M. (2016, November 15). Efficacy and safety of deflazacort vs prednisone and placebo for Duchenne muscular dystrophy. Retrieved January 18, 2018, from http://n.neurology.org/content/87/20/... • Study on Exercise: • Jansen, M., Alfen, N. V., Geurts, A. C., Groot, I. J. (2013, July 24). Assisted Bicycle Training Delays Functional Deterioration in Boys With Duchenne Muscular Dystrophy: The Randomized Controlled Trial No Use Is Disuse . Retrieved January 18, 2018, from https://www.researchgate.net/publicat... • References: • Le Guiner, C., Servais, L., Montus, M., Larcher, T., Fraysse, B., Moullec, S., ... Koo, T. (2017, July 25). Long-term microdystrophin gene therapy is effective in a canine model of Duchenne muscular dystrophy. Retrieved January 18, 2018, from https://www.nature.com/articles/ncomm... • McDonald, C. M., Henricson, E. K., Abresch, R. T., Florence, J., Eagle, M., Gappmaier, E., . . . Peltz, S. W. (2013, July 17). The 6‐minute walk test and other clinical endpoints in duchenne muscular dystrophy: Reliability, concurrent validity, and minimal clinically important differences from a multicenter study. Retrieved January 18, 2018, from http://onlinelibrary.wiley.com/doi/10... • Ropars, J., Lempereur, M., Vuillerot, C., Tiffreau, V., Peudenier, S., Cuisset, J., . . . Brochard, S. (2016, September 13). Muscle Activation during Gait in Children with Duchenne Muscular Dystrophy. Retrieved January 18, 2018, from http://journals.plos.org/plosone/arti... • Ruiten, H. J., Straub, V., Bushby, K., Guglieri, M. (2014, September 3). Improving recognition of Duchenne muscular dystrophy: a retrospective case note review. Retrieved January 18, 2018, from http://adc.bmj.com/content/early/2014... • Sienkiewicz, D., Kulak, W., Okurowska-Zawada, B., Paszko-Patej, G., Kawnik, K. (2015, July). Duchenne muscular dystrophy: current cell therapies. Retrieved January 18, 2018, from https://www.ncbi.nlm.nih.gov/pmc/arti... • Sussman, M. (2002). Duchenne Muscular Dystrophy. Journal of the American Academy of Orthopaedic Surgeons, 10(2), 138-151. • Vohra, R. S., Lott, D., Mathur, S., Senesac, C., Deol, J., Germain, S., . . . Vandenborne, K. (2015, June 23). Magnetic Resonance Assessment of Hypertrophic and Pseudo-Hypertrophic Changes in Lower Leg Muscles of Boys with Duchenne Muscular Dystrophy and Their Relationship to Functional Measurements. Retrieved January 18, 2018, from http://journals.plos.org/plosone/arti...

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