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Colchicine SIDE EFFECTS Colchicine DOSAGE Colchicine USES
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All about COLCHICINE medicine: colchicine dosage (1mg, 0.5 mg), colchicine uses, colchicine side effects, colchicine contraindications, colchicine interactions, colchicine mechanism of action (moa). • We will answer questions such as: What is colchicine, what is colchicine for, how to take colchicine, when to take colchicine. • The commercial names of colchicine are: colchicine seid, colchiquim, sixol, ticolcin, Colcrys, Mitigare, Gloperba. • Mechanism of action of Colchicine: • It reduces the inflammatory response consecutive to the deposition of urate crystals in the joints, since it decreases the leukocyte flow, inhibits the phagocytosis of the urate microcrystals, thus reducing the production of lactic acid avoiding an acid pH, and with it the precipitation of the urate crystals. • Therapeutic Indications and Posology of Colchicine: • Oral route. • Adults: • Acute gout attack: 1 mg at the first sign of gout attack. If pain relief is not achieved, administer 1 mg 1 or 2 hours after the first intake. • Maximum: 2 mg per day, maximum dosage pattern 4 days in a row, without exceeding a total accumulated dose of 6 mg during the 4 days,. • Preventive treatment of gout attacks during initial therapy with allopurinol or uricosurics: 1 mg per day. • Periodic illness or familial Mediterranean fever: from 1 to 1 mg per day (in 2 daily doses or in 1 single dose). • Treatment of chronic gout: 1 mg per day • • BIBLIOGRAPHY: The information provided is true, safe and rigorous extracted from the data sheets provided by the government agencies; it has been written by a doctor taking into account the clinical information of all the medicines authorized and marketed in Spain, Europe and the United States. • For more detailed information on each drug, the corresponding Technical File authorized by the AEMPS, the EMA or the FDA must be consulted. • https://www.aemps.gob.es/ • https://cima.aemps.es/cima/publico/ho... • https://www.ema.europa.eu/en • https://www.hma.eu/ • https://www.fda.gov/ • https://www.nlm.nih.gov/ • https://medlineplus.gov/ • https://www.redeami.net/web/homes/eam... • https://eu-jamrai.eu/ • We remind you that before using any medication you should consult your doctor or pharmacist.
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