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【Folate Metabolism→Explained】Methotrexate Mechanism of Action Updated 【AntiCancer Pharmacology】
>> YOUR LINK HERE: ___ http://youtube.com/watch?v=Bdi9lTWTUmU
Join Dr. Chat Perche, MD, PhD, for a high-speed study session. • This video is designed so that by the time you finish watching, you'll have perfectly memorized the frequently asked exam topics. • By the end of this video, you'll have perfectly memorized about Methotrexate. • It masquerades as Folate, and induces damage to DNA. • Do you want to know the mechanism of action? • Discover the mechanism of action of Methotrexate in this concise video. • We explore its role as an antimetabolite, its interaction with folate metabolism, and its impact on DNA synthesis. • Learn how Methotrexate functions in cancer treatment, immune system suppression, and its effects on human T cells. • Ace your exams by understanding the core concepts without unnecessary complexities. Watch now and boost your knowledge efficiently! 📚✨ • #cancertreatment #biochemistrynotes #pharmacologymadeeasy • 【Notes】 • ▹This video was created based on data as of January 2024, with the purpose of supporting medical students in their exam preparations. • ▹Please note that thanks to the tireless efforts of researchers worldwide, this data is updated daily. ▹Unauthorized reproduction is prohibited. • 【Contents】 • 00:00 Methotrexate is an antimetabolite. What is an antimetabolite? • 01:02 Methotrexate, the mechanism of action • 01:06 Folate has an important role in DNA synthesis. Why? • 02:25 Methotrexate is taken up by DHFR, why? • 02:49 Methotrexate: as an immunosuppressor, what's the mechanism of action? • 03:45 Methotrexate functions in the S phase of the cell cycle. • 【Reference and figure】I express my gratitude and respect for your wonderful achievements. • 1. Britannica, The Editors of Encyclopaedia. antimetabolite . Encyclopedia Britannica, 20 Nov. 2017, https://www.britannica.com/science/an.... Accessed 9 January 2024. • 2. Koźmiński P, Halik PK, Chesori R, Gniazdowska E. Overview of Dual-Acting Drug Methotrexate in Different Neurological Diseases, Autoimmune Pathologies and Cancers. Int J Mol Sci. 2020 May 14;21(10):3483. doi: 10.3390/ijms21103483. PMID: 32423175; PMCID: PMC7279024. • 3. Bennett BC, Wan Q, Ahmad MF, Langan P, Dealwis CG. X-ray structure of the ternary MTX.NADPH complex of the anthrax dihydrofolate reductase: a pharmacophore for dual-site inhibitor design. J Struct Biol. 2009 May;166(2):162-71. doi: 10.1016/j.jsb.2009.01.001. PMID: 19374017; PMCID: PMC2738603. • 4. Li GM, Presnell SR, Gu L. Folate deficiency, mismatch repair-dependent apoptosis, and human disease. J Nutr Biochem. 2003 Oct;14(10):568-75. doi: 10.1016/s0955-2863(03)00115-3. PMID: 14559107. (https://www.sciencedirect.com/science...) • 5. BogHog, Folic acid compared to methotrexate. Wikipedia, 28/Feb/2015. https://commons.wikimedia.org/wiki/Fi... • 6. Carmen Avendaño, J. Carlos Menéndez, Chapter 2 - Antimetabolites, Editor(s): Carmen Avendaño, J. Carlos Menéndez, Medicinal Chemistry of Anticancer Drugs, Elsevier, 2008, Pages 9-52, ISBN 9780444528247,https://doi.org/10.1016/B978-0-444-52.... (https://www.sciencedirect.com/science...) • 7. NANCY OLSEN, MD. Low'dose methotrexate: antiinflammatory or immunosuppressive?, CLEVELAND CLINIC JOURNAL OF MEDICINE, 1990, VOLUME 57 NUMBER 3, page 245-246. • 8. Cronstein, B.N., Aune, T.M. Methotrexate and its mechanisms of action in inflammatory arthritis. Nat Rev Rheumatol 16, 145–154 (2020). https://doi.org/10.1038/s41584-020-03.... • 9. Budzik GP, Colletti LM, Faltynek CR. Effects of methotrexate on nucleotide pools in normal human T cells and the CEM T cell line. Life Sci. 2000;66(23):2297-307. doi: 10.1016/s0024-3205(00)00559-2. PMID: 10855951. • 10. Friedman B, Cronstein B. Methotrexate mechanism in treatment of rheumatoid arthritis. Joint Bone Spine. 2019 May;86(3):301-307. doi: 10.1016/j.jbspin.2018.07.004. Epub 2018 Aug 3. PMID: 30081197; PMCID: PMC6360124. • #methotrexate #folicacid #folate
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