MUT3

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The aquaporins (AQPs) are a family of small membrane-spanning proteins (monomer size ∼30 kDa) that are expressed at plasma membranes in many cells types involved in fluid transport. Aquaporins appear to assemble in membranes as homotetramers in which each monomer, consisting of six membrane-spanning α-helical domains with cytoplasmically oriented amino and carboxy termini. • The gating of aquaporins is necessary to keep cells hydrated during periods of drought. The mechanism in some aquaporins involves the dephosphorylation of certain serine residues, causing the protein to change shape. This change in shape causes the tunnel of the protein to close and not allow any water to pass through. In oocytes it transport glycerol and to some extent urea, along with water. Many mammalian AQPs, including AQP1, AQP2, AQP4, AQP5 and AQP8, function primarily as bidirectional water-selective transporters. • #CSIR #ICAR #ICMR #CELLBIO

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