Youtor
Bathroom Transfers for Wheelchair Users
>> YOUR LINK HERE: ___ http://youtube.com/watch?v=Ebu8W8Osuxk
Duchenne Muscular Dystrophy (DMD) is an genetic muscle-wasting disease that leads to disability and early death. In all cases of this disease, the gene for a protein known as dystrophin is mutated. How does a dysfunctional dystrophin gene cause DMD? Find out in this episode of Medicurio. • Interesting to note: Becker's Muscular Dystrophy is a similar disease, but with much milder symptoms. People who have this disease also have a mutation in the dystrophin gene, but instead of making completely useless dystrophin, the protein is still semi-functional. People with Becker's dystrophy have much slower muscle wasting and live into the 50's and 60's. • Cool links to check out to learn and donate to DMD research: • Cure Duchenne: http://www.cureduchenne.org/ • Muscular Dystrophy Canada: http://www.muscle.ca/ • Muscular Dystrophy Association: https://www.mda.org/ • Excellent video on how Exon Skipping works, courtesy of Cure Duchenne: • Prosensa's Video Animation on Exon Sk... • The full process to get from DNA to protein is outlined in the central dogma of biology. • 1. Genes are in the nucleus of the cell as DNA. • 2. RNA polymerases make an RNA copy of the gene, known as the primary RNA transcript or pre-mRNA. • 3. The primary RNA transcript undergoes some processing, such as splicing exons together. • 4. mRNA exits the nucleus and into the cytoplasm, where ribosomes read the mRNA one codon at a time. Each codon corresponds to a certain amino acid or a stop codon. • 5. Amino acids are linked together until a stop codon is reached, finishing the protein. • You can find a realistic animation of this process here, courtesy of the DNA Learning Centre: • The Central Dogma of Biology
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