How High Can You Go

>> YOUR LINK HERE: ___ http://youtube.com/watch?v=FzC1CtkSENI

In this lecture from ResusX: Reset, Dr. Salim Rezaie explores the question, Norepinephrine: How High Can You Go? by reviewing four retrospective studies on the maximum dose of norepinephrine in critically ill patients. Despite the absence of randomized clinical trials, Dr. Rezaie discusses the findings from these studies, where the highest recorded doses ranged from 1.4 to 2.91 micrograms per kilogram per minute. • Notably, a case report even documented doses as high as 30 micrograms per kilogram per minute without organ damage. Survival rates varied from 17% to 52% among patients on doses greater than one microgram per kilogram per minute. Dr. Rezaie emphasizes that while there is no defined maximum dose, escalating norepinephrine doses should prompt a thorough assessment of potential underlying causes, including accurate blood pressure measurement, echocardiography, source control, acidosis correction, and consideration of sedation adjustments. • Overall, he advocates for a cautious approach, using high doses sparingly and in conjunction with a comprehensive patient assessment. • 00:00 Introduction to Norepinephrine Dosage • 01:04 The Lack of Clinical Trials on Norepinephrine Dosage • 01:17 Review of Retrospective Studies on Norepinephrine Dosage • 03:35 Case Report: High-Dose Norepinephrine in Late Shock • 04:59 Summary of Findings on Norepinephrine Dosage • 05:50 Considerations Before Using High Doses of Norepinephrine • 06:13 Assessing for Causes of Hypotension • 08:02 Final Thoughts on Norepinephrine Dosage • 08:53 Conclusion • To watch more videos from the ResusX: Reset conference, check out https://www.resusx.com/resusx-reset-r... • Hashtags: • #Norepinephrine, #CriticalCare, #EmergencyMedicine, #VasopressorTherapy, #RetrospectiveStudies, #HighDoseNorepinephrine, #SurvivalAfterShock, #Vasopressors, #StressDoseSteroids, #ClinicalTrials, #SepticShock, #SourceControl, #AcidosisManagement, #SedationAdjustments, #AdrenalInsufficiency

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