Ep 24 Top 200 Drugs in 2 Hours Part 6 of 7 Cardio Pharmacology
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This one-day, two hour seven lecture series provides a basic understanding of how to recognize common drug names, understand the basic classifications, and quickly memorize them for exams. The print, e-book, and audiobooks these lectures are based on, Memorizing Pharmacology: A Relaxed Approach, can be found here https://www.amazon.com/Memorizing-Pha... • • Full Transcript: • • Let's go over chapter [six] cardiovascular. I'm going to start with just three OTC medications. There really aren't that many Start with OTC anti hyperlipidemia, you'll see these called anti Cholesterol drugs, or Things like that There's, I put that there over-the-counter But they're also by prescription, and it's a little bit goofy so the omega-3 acid ethyl esters are actually Lovaza, which is a Which is a brand name for the prescription Omega-3 acid ethyl esters, and then niacin has a brand name of Niaspan, but you can still find Niacin and fish oil Over the counter which have essentially the same thing. So what's the what's the advantage of getting the prescription? the FDA has tested those particular Medications the omega-3 and the niacin and to know that it's FDA-approved to know that it's at that level of purity [That] can be an advantage The big OTC Cardio drug is something that's been around for a long time Which is aspirin, but it's in used a little bit differently so instead of the 325 milligram aspirin as an analgesic or for fever We're talking about 81 milligrams and We used to have something called children's aspirin. We now know that aspirin can cause Reye's syndrome spelled capital R-e-y-e-s, but pronounced rise like I rise in the morning and This aspirin at 81 milligrams does a good job of keeping the platelets from getting sticky, and there's good outcomes with morbidity/mortality [in] terms of cardiac events like heart attack like stroke, so a daily aspirin The physician tells the patient to take it but they can just find them over-the-counter But a very inexpensive way to help the patient and then just a reminder that this brand name, Ecotrin is enteric coated aspirin to help protect the stomach From this non-steroidal, but again this aspirin is not being used for pain is not being used for fever. It's being used because of its ability to thin the platelets Well the first prescription group we have is going to be the diuretics and With the diuretics what you want to do is in your mind picture the glomerulus and from the glomerulus We want to go to the proximal convoluted tubule then to the Loop of Henle then to the distal convoluted tubules then to the collecting duct and I say distal convoluted tubule and collecting duct as separate but Really, we're talking early distal convoluted tubule [It] doesn't really matter as much as getting the order right and the reason this order is so important is that diuresis Decreases as you get further away from the glomerulus So if you think about being on a waterslide at the top of the waterslide there's a lot of water coming out into that slide But as you get to the bottom there's just a little trickle down at the bottom same thing's true here, so the osmotic diuretic Mannitol [brand] Osmitrol. This is used for brain edema [a] very serious event but not used that often So, the next group are the loop diuretics they work in the Loop of Henle, and we have furosemide and This has a stem -semide stem. So there's torsemide, furosemide other diuretics and the the brand name comes from the fact that it lasts six hours so, Lasix and this loop diuretic is used more for congestive heart failure or Severe edematous states where there's a lot of fluid that needs to be taken off Or it might be used if the fluid needs to be taken off quickly When you're talking about treating hypertension. You could use furosemide, but more likely you'll use a thiazide diuretic like hydrochlorothiazide Abbreviated HCTZ One of the brand names is Microzide, it was the capsule form and These thiazide diuretics are more used for somebody who has hypertension So if you look at again the diuresis, the mannitol would be the most furosemide might be a little bit less Hydrochlorothiazide less than that The issue with both furosemide and hydrochlorothiazide is that they decrease Potassium and because they decrease potassium we need to in some way get that potassium back So we have what's called a potassium sparing diuretic Triamterene is one. It doesn't cause a significant amount of diuresis because it really works closer to the collecting duct and That triamterene is paired as a combination product with hydrochlorothiazide again the -thiazide stem and Triamteren's brand name was Dyrenium and You take part of the hydrochlorothiazide or the ending to make the brand name Dyazide, so this was Dyrenium or used to be But we don't really see [that] brand name on [the] shelf ever potassium sparing, so Some triamterene alone is potassium sparing spironolactone is another one....
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