Eosinophilic granulomatosis with polyangiitis ChurgStrauss Syndrome

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📌 𝐅𝐨𝐥𝐥𝐨𝐰 𝐨𝐧 𝐈𝐧𝐬𝐭𝐚𝐠𝐫𝐚𝐦:- / drgbhanuprakash • 📌𝗝𝗼𝗶𝗻 𝗢𝘂𝗿 𝗧𝗲𝗹𝗲𝗴𝗿𝗮𝗺 𝗖𝗵𝗮𝗻𝗻𝗲𝗹 𝗛𝗲𝗿𝗲:- https://t.me/bhanuprakashdr • 📌𝗦𝘂𝗯𝘀𝗰𝗿𝗶𝗯𝗲 𝗧𝗼 𝗠𝘆 𝗠𝗮𝗶𝗹𝗶𝗻𝗴 𝗟𝗶𝘀𝘁:- https://linktr.ee/DrGBhanuprakash • Eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome) • Definition: a multisystem disease characterized by necrotizing granulomatous vasculitis with eosinophilia, which most commonly involves the lungs and the skin but can also affect the renal, cardiovascular, gastrointestinal, central, and peripheral nervous systems. • Etiology: unknown • Clinical features • • Severe allergic asthma attacks (chief complaint) • • Allergic rhinitis/sinusitis • • Skin nodules, palpable purpura • • Pericarditis • • Gastrointestinal involvement: bleeding, ischemia, perforation • • Pauci-immune glomerulonephritis • • CNS: impaired mental status, mononeuritis multiplex (loss of motor and sensory function) • Diagnostics • • Peripheral blood eosinophilia • • ↑ IgE level • • Circulating MPO-ANCA/pANCA (∼ 40% of cases) • • Biopsy (confirmatory test): tissue eosinophilia and necrotizing granuloma • Treatment: immunosuppression with glucocorticoids; possible in combination with cyclophosphamide • Churg-Strauss syndrome = pANCA and polyneuropathy (foot or wrist drop), allergic rhinitis/sinusitis/asthma, vasculitis, eosinophilia, and skin nodules • #Eosinophilicgranulomatosis #pathologyvideos #usmlevideos #usmlestep1videos #patholectures #granulomatosispathlogy #animatedmedicalvideos #pathologyanimatedvideos #drgbhanuprakash

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