Acromegaly and Gigantism Pathology

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📌 𝐅𝐨𝐥𝐥𝐨𝐰 𝐨𝐧 𝐈𝐧𝐬𝐭𝐚𝐠𝐫𝐚𝐦:- / drgbhanuprakash • 📌𝗝𝗼𝗶𝗻 𝗢𝘂𝗿 𝗧𝗲𝗹𝗲𝗴𝗿𝗮𝗺 𝗖𝗵𝗮𝗻𝗻𝗲𝗹 𝗛𝗲𝗿𝗲:- https://t.me/bhanuprakashdr • 📌𝗦𝘂𝗯𝘀𝗰𝗿𝗶𝗯𝗲 𝗧𝗼 𝗠𝘆 𝗠𝗮𝗶𝗹𝗶𝗻𝗴 𝗟𝗶𝘀𝘁:- https://linktr.ee/DrGBhanuprakash • Acromegaly and Gigantism - Pathology • Development of abnormally large size due to the excessive growth of the long bones. Caused by hyperpituitarism before the completion of the normal ossification process (commonly seen in children). • This is in contrast to acromegaly, which results from hyperpituitarism after the completion of the ossification process (commonly seen in adults). Typically accompanied by muscular weakness and sexual impotence. • Most common cause is pituitary-associated gigantism. • Acromegaly results from persistent hypersecretion of growth hormone (GH). Excess GH stimulates hepatic secretion of insulin-like growth factor 1 (IGF-1), which causes most of the clinical manifestations of acromegaly. • The most common cause of acromegaly is a somatotroph (growth hormone [GH]-secreting) adenoma of the anterior pituitary. These adenomas account for about one-third of all hormone-secreting pituitary adenomas • The clinical features of acromegaly are attributable to high serum concentrations of both growth hormone (GH) and insulin-like growth factor 1 (IGF-1), which is GH-dependent. Excess GH and IGF-1 have both somatic and metabolic effects. The somatic effects include stimulation of growth of many tissues, such as skin, connective tissue, cartilage, bone, viscera, and many epithelial tissues. • ●The metabolic effects include nitrogen retention, insulin antagonism, and lipolysis. • #acromrgaly #gigantism #pitutarygland #endocrinology #acromegalyandgigantism

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