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In this part 1 of amyloidosis i have described the definition, historical aspects and properties of Amyloid. Visit http://ilovepathology.com / for more topics in Pathology! • ***Follow me**** • Twitter : / vijaypatho • / ilovepathology2 • Facebook: / ilovepathology • AMYLOIDOSIS 1 • Is a condition associated with number of inherited and inflammatory disorders • In which There is deposition of Predominantly Extracellular fibrillar proteins RESULTING IN Tissue damage functional compromise • These are Aggregates of MISFOLDED proteins and are insoluble. • historical aspects: • “amylim” a latin word means “starch” • Matthias Schleiden a German Botanist was the first to use the term “amyloid” in botany, for starch, referring to“starch-like”. • German pathologist Rudolf Virchow (1804 - 1881) applied it in the medical literature in 1854. • used the word “Amyloid” to describe some deposits in nervous system which showed the same color reaction with iodine and sulfuric acid, i.e. a change from brown to blue, typical to starch • In the later years it was found that the chemical nature was unrelated to starch but proteins! • Yet.. The name “amyloid” still remains • Probably because of Virchow was considered as one of the most valued scientists of his time • In the later years it was found that the chemical nature was unrelated to starch but proteins! • Amyloid proteins: Properties • Amyloid is not a single entity • More than 20 different proteins can aggregate to form fibrils. • The mechanisms of formation are different. • Therefore amyloidosis should not be considered as a single disease… rather, a group of diseases with deposition of similar appearing proteins

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