Youtor
Drug induced Liver Disease DILI clinical pharmacy
>> YOUR LINK HERE: ___ http://youtube.com/watch?v=KL6gFZCAPFs
Drug Induced Liver Injury : • #drug-induced_liver_disease #liverfunctiontest #drug_induced_liver_injury_explained • • The incidence of Drug-Induced Liver Injury (DILI) is a growing challenge because of the ever-increasing number of drugs used in medical care. ‘’ Injury to the liver that is associated with impaired liver function caused by exposure to a drug or another noninfectious agent ’’. • Drug-induced liver disease occurs as several different clinical presentations • Causes of Drug-Induced Liver Disease • • Idiosyncratic reactions • • Allergic hepatitis • • Toxic Hepatitis • • Chronic active toxic hepatitis • • Toxic cirrhosis • FDA criteria for DILI: • • ALT/SGPT = 3 times upper normal level • • ALP = 2 times upper normal level • • TBL = 2 times upper normal level • Hepatotoxicity • Acute and chronic liver disease • Why is Hepatotoxicity missed during clinical trials ? • • PATTERNS OF DRUG-INDUCED LIVER DISEASE: • 1. Hepatocellular injury • a. Centrolobular necrosis • b. Steatohepatitis (steatonecrosis) • C. phospholipidosis • d. Generalized hepatocellular necrosis • • -- Causes of Drug-Induced Liver Disease: • Medication (over-the-counter and prescription) that have been associated with drug-induced liver disease includes: • Acetaminophen • Aspirin, ibuprofen, naproxen sodium when taken excessively or taken with alcohol • NSAIDs • Steroids • Anti-viral drugs for HIV infection • Steroids • Arthritis drug like methotrexate • Antifungal drugs • Niacin • Antibiotics such as erythromycin • Statin • Vitamins A • Oral contraceptive pills • Chemotherapy • Herbal supplements that contain Aloe Vera, cascara, comfrey, or kava • Chemical and solvents • • MECHANISMS OF DRUG-INDUCED LIVER DISEASE : • 1. Stimulation of autoimmunity • 2. Idiosyncratic reactions • 3. Disruption of calcium homeostasis cell membrane injury • 4. Metabolic activation of the Cytochrome p450 enzymes • 5. Stimulation of apoptosis • 6. Mitochondrial injury • 7. Liver neoplastic disease • Host factors enhancing susceptibility • Hapten hypothesis • p-i concept • Clinical Manifestations for Drug Induced Liver Injury • Clinical Types • Hepatitis (Cytotoxic) – Necrosis/Apoptosis • Cholestasis – Jaundice: Prolonged • Mixed Hepatitis/Cholestasis • Pathological Manifestations in Drug Induced Liver Injury • DIAGNOSIS of Drug Induced Liver Injury • Elevated aminotranferase levels with acute Hepatocellular injury • • In drug induced hepatitis, AST and ALT levels increase steadily within 7-14 days. • — Drugs causing increase in AST: – Acetaminophen – NSAIDs – ACE inhibitors – Nicotinic acid – Sulfonamides – Erythromycin – Griseofulvin – Fluconazole. • Asymptomatic elevations in aminotransferase- Methyldopa • Phenytoin • Statins • Sulfonamides • Salicylates • Sulfonylureas • Quinidine • TREATMENT of Drug Induced Liver Injury • MONITORING in Drug Induced Liver Injury • – An Approach to Determining a Drug-Monitoring Plan to Detect Hepatotoxicity • • 2. Toxic cirrhosis • 3. Cholestatic injury • 4. Mixed hepatocellular and Cholestatic injury • • Drug-Induced Liver Disease, Causes, Signs and Symptoms, Diagnosis and Treatment. • Approach to drug induced liver injury and cell mediated hepatitis | UCLA Digestive Diseases • Drug-induced liver injury and cross-reactivity across drugs/organs • Fatty Liver: Symptoms, Causes and Treatment • LFT Test | High Bilirubine | High SGPT | Liver function test in Hindi | LFT Test in Hindi • DRUG INDUCED LIVER INJURY (Hepatotoxicity) causative agents, mechanisms and pathology • Drug-Induced Liver Injury: Intrinsic and Idiosyncratic • Drug-Induced Hepatitis #liverfunctiontest • drug-induced liver disease • drug induced liver disease • drug induced liver disease عبد المتعال#3 • drug induced liver damage • drug induced liver disease explained • drug induced liver injury explaine • drug induced liver disease • drug induced liver injury in children • drug-induced liver injury • drug induced liver injury guidelines. • drug induced liver disease ppt • drug induced hepatotoxicity • illegal drugs that cause liver damage. • drug induced liver injury pdf. • DRUG INDUCED LIVER INJURY introduction • drug induced liver disease عبد المتعال, • drug induced liver disease explained • ,liver disease • liver function tests,liver function test biochemistry,liver function test in hindi • • #askyourpharmacist #askyourpharmacistmaryum #maryum #maryumsharish #pharmacy #pharmacist #pharmacistlife #pharma #doctorofpharmacy #bpharma #dpharmacy #pharmacytech #pharmd #DPharma #B-Pharma #pharmd #pharmacynotes #pharmacynews #pharmacymcqs #pharmacyexam #pharmacyquestionanswer #pharma_tutorial #pharmafact #CollegeofPharmacy #QuestionstoAskYourPharmacist #pharmaceutics #drugs #bigpharma #healthcare #pharmacystudent #farmacia #pharmacylife #pharmacytechnician #doctors #pharmacyschool #pharmaceuticals #science #medicalstudent #mbbs #coronavirus #covid #nursing #pharmacology #Pharmacodynamic #Pharmacokinetic #medicine #clinical #physicians #indian_pharmacy #medschool #medstudents #medtiktok #Telemedicine
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