Medicinal Chemistry II 25 Antihypertensive Agents Part 02 Quinapril Methyldopa Colinidine

>> YOUR LINK HERE: ___ http://youtube.com/watch?v=KOzeoBbZj5w

Download the Solution Pharmacy Mobile App to Get All Uploaded Notes, Model Question Papers, Answer Papers, Online Tests and other GPAT Materials - https://play.google.com/store/apps/de... • Antihypertensive drugs are medications used to lower high blood pressure (hypertension). Hypertension is a significant risk factor for various cardiovascular diseases, including heart attacks, strokes, and heart failure. These drugs work by targeting different mechanisms that regulate blood pressure, such as reducing cardiac output, relaxing blood vessels, or decreasing fluid volume. • 1. Quinapril: • Chemistry: • Quinapril is a prodrug belonging to the class of drugs known as angiotensin-converting enzyme (ACE) inhibitors. Its chemical structure includes a proline-like moiety, which is essential for its activity, as well as an ester group that is hydrolyzed in the body to form the active metabolite, quinaprilat. • Mechanism of Action: • Quinapril works by inhibiting the action of the angiotensin-converting enzyme (ACE). This enzyme converts angiotensin I to angiotensin II, a potent vasoconstrictor. By inhibiting ACE, quinapril reduces angiotensin II levels, leading to vasodilation, decreased blood pressure, and reduced aldosterone secretion. • Clinical Uses: • Quinapril is primarily used to treat hypertension. It may also be prescribed to manage heart failure. • 2. Methyldopa: • Chemistry • Methyldopa is an alpha-2 adrenergic agonist. Its chemical structure includes a methylated derivative of levodopa, a precursor of dopamine. • Mechanism of Action: • Methyldopa acts on central alpha-2 adrenergic receptors in the brain. By stimulating these receptors, it reduces sympathetic outflow, leading to decreased peripheral resistance and blood pressure. • Clinical Uses: • Methyldopa is used to treat hypertension, particularly in pregnant women, as it has a lower risk of adverse effects on the fetus compared to some other antihypertensive drugs. • 3. Clonidine: • Chemistry: • Clonidine is also an alpha-2 adrenergic agonist. Its chemical structure is related to imidazoline. • Mechanism of Action: • Clonidine acts primarily as a central alpha-2 adrenergic agonist. It stimulates these receptors in the brain, leading to decreased sympathetic outflow, reduced peripheral resistance, and lower blood pressure. • Clinical Uses: • Clonidine is used to treat hypertension. It is also used in the management of opioid withdrawal symptoms and as an adjunctive therapy for certain psychiatric conditions. • These drugs, Quinapril, Methyldopa, and Clonidine, work through different mechanisms to lower blood pressure. The choice of drug and dosage depends on various factors, including the patient's specific medical condition and individual response to the medication. Always consult a healthcare professional for proper diagnosis and treatment. • Get in touch with the solution by just clicking the following links- • Facebook Group- / solutionpharamcy • Mobile App - https://play.google.com/store/apps/de... • New Channel (Pharmacy Dictionary) / @pharmacydictionary • E-Mail for official and other work - [email protected] • #solutionpharmacy #Pharmacologyclass #Pharmacognosyvideos #GPAT

#############################

New on site