Is it a neurobiology of long term memory

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Latest neuroscience publication links complexes of KIBRA and PKMζ to long term memory. • 👉 Neuroscience news: • Paralyzed patients swim, AI codes, Ar... • 👉Time codes: • 0:00 - Introduction • 1:19 - Long-term potentiation (LTP) and depression • 2:20 - NMDA-dependent LTP • 3:40 - LTP maintainance concept • 5:15 - Protein kinase (PKMζ) role in LTP • 6:30 - Role of KIBRA in LTP • 6:58 - LTP maintainance via KIBRA-PKMζ and further steps • 8:26 - Slice electrophysiology followed by immunocytochemistry of KIBRA-PKMζ • 10:51 - Behind the scenes of a scientific paper • 11:52 - Slice electrophysiology of KIBRA-PKMζ with ζ-stat • 12:26 - In-vivo mice behavioural experiments. • 12:45 - Behind the scenes of active-place avoidance experiments • 13:06 - Erasing memories in-vivo by blocking KIBRA-PKMζ • 14:04 - Behind the scenes of paper writing • 14:40 - Difference between science and fake sciences. • 👉 References from the video: • Wireless behaviour control: • WIRELESS BEHAVIOUR CONTROL DOES EXIST! • Top 3 cited neuroscience papers: • TOP 3 BASIC NEUROSCIENCE PAPERS • Neuroscience of propaganda: • Neuroscience of Propaganda. How to re... • ➡️Original publication: • https://www.science.org/doi/10.1126/s... • ➡️ Original scientific abstract • How can short-lived molecules selectively maintain the potentiation of activated synapses to sustain long-term memory? Here, we find kidney and brain expressed adaptor protein (KIBRA), a postsynaptic scaffolding protein genetically linked to human memory performance, complexes with protein kinase Mzeta (PKMζ), anchoring the kinase’s potentiating action to maintain late-phase • long-term potentiation (late-LTP) at activated synapses. Two structurally distinct antagonists of KIBRA-PKMζ dimerization disrupt established late-LTP and long-term spatial memory, yet neither measurably affects basal synaptic transmission. Neither antagonist affects PKMζ-independent • LTP or memory that are maintained by compensating PKCs in ζ-knockout mice; thus, both agents require PKMζ for their effect. KIBRA-PKMζ complexes maintain 1-month- old memory despite PKMζ turnover. Therefore, it is not PKMζ alone, nor KIBRA alone, but the continual interaction between the two that maintains late-LTP and long-term memory • #science #neuroscience #brain #yuri_neuro

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