Hyperprogression

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Hyperprogression is an increased cancer growth rate caused by immune checkpoint inhibitors (PD-1/PD-L1) like Opdivo and Keytruda, occurring in 4-29% of treated patients. It differs from pseudoprogression, as hyperprogression leads to a significant increase in tumor size and new tumor locations, reducing patient lifespan. Studies suggest a link to MDM2 gene amplification, EGFR aberrations, and tumor-associated macrophages (TAMs). Removing part of the antibody that binds to TAMs can prevent hyperprogression. Drugs like clodronate, CSF-1R inhibitors, Anti-MARCO antibodies, and natural substances like 6-Gingerol and Silibin may help counter TAMs. Immunotherapy can cause serious side effects, requiring patient awareness and monitoring. • Reference: Jason R. Williams, 15 Oct 2019, The Immunotherapy Revolution: The Best New Hope For Saving Cancer Patients’ Lives. • https://williamscancerinstitute.com/h... • #cancercells #cancerpatient

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