KarMMaRW A study of realworld treatment patterns in heavily pretreated patients with RRMM











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KarMMa-RW: A study of real-world treatment patterns in heavily pretreated patients with relapsed and refractory multiple myeloma (RRMM) and comparison of outcomes to KarMMa • KarMMa is a pivotal, open-label, single-arm, multicenter, multinational, Phase 2 study evaluating the efficacy and safety of ide-cel in adult patients with relapsed and refractory multiple myeloma (RRMM) in North America and Europe. The primary endpoint of the study is overall response rate as assessed by an independent review committee (IRC) according to the International Myeloma Working Group (IMWG) criteria. • Ide-cel is a BCMA-directed genetically modified autologous CAR T cell immunotherapy. The ide-cel CAR is comprised of a murine extracellular single-chain variable fragment (scFv) specific for recognizing BCMA, attached to a human CD8 α hinge and transmembrane domain fused to the T cell cytoplasmic signaling domains of CD137 4-1BB and CD3-ζ chain, in tandem. Ide-cel recognizes and binds to BCMA on the surface of multiple myeloma cells leading to CAR T cell proliferation, cytokine secretion, and subsequent cytolytic killing of BCMA-expressing cells. • Results from the KarMMa-RW study confirm that there is no clear SoC for heavily pretreated RW RRMM pts and responses are suboptimal with currently available therapies. Ide-cel showed deep, durable responses and significantly improved PFS in RRMM pts, representing a potential new tx option in RRMM. • Please subscribe to our channel! • Subscribe to International Myeloma Foundation: http://bit.ly/XlUtPE • • Visit our website at: https://www.myeloma.org • • Find us online: • Facebook:   / myeloma   • Google+: http://gplus.to/imfmyeloma • IMF on twitter: @IMFMyeloma (  / imfmyeloma  ) • Dr. Durie on twitter: @BrianDurieMD (  / brianduriemd  ) • • Support the IMF! http://bit.ly/WskQHC • Category • Nonprofits Activism • License • Standard YouTube License

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