Third vaccine dose













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Third dose trial, Cov-Boost study • https://www.bbc.co.uk/news/health-571... • Need for third dose autumn or winter? • Factors • Variants and vaccine efficacy • Longevity of protection • Trial starts in June • N = 3,000 • All ages who had their first dose in December or January • Prof Saul Faust, chief investigator, University of Southampton • It could be that some age groups may not need a booster and others do • The aim is to find out whether there should be a booster campaign • and which vaccine to use • Vaccines to be trailed • AstraZeneca (adenovirus vector) • Pfizer (mRNA) • Moderna (mRNA) • Novavax (moth produced spike protein) • Janssen (adenovirus vector) • Valneva (inactivated virus) • CureVac (mRNA) • Half doses will also be tested • Placebo group • Hoped to protect against all current variants • 18 sites across the UK • Participants will keep diaries of any side-effects • Immune assessments at one, three and twelve months • UK, variant hotspots to get • https://www.bbc.co.uk/news/uk-57172139 • Surge tests and vaccinations • Areas identified, analysing wastewater and travel patterns • an incredibly sensitive biosecurity surveillance system • India variant, = 2,967 • Bedford • Burnley • Hounslow • Kirklees • Leicester • North Tyneside • Glasgow and Moray • UK official figures • https://coronavirus.data.gov.uk • First dose, 70.2% • Second dose, 39.6% • England and Wales, over 34s can now book • US • Variants • https://covid.cdc.gov/covid-data-trac... • FDA, Pfizer storage • https://www.fda.gov/news-events/press... • FDA authorizing undiluted, thawed vials to be stored in the refrigerator at 2°C to 8°C (35°F to 46°F) for up to 1 month • Up from 5 days • (8% not returned for second dose)

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