Youtor
Molecular Dynamics Simulations of Bacterial Chemosensory Array
>> YOUR LINK HERE: ___ http://youtube.com/watch?v=NktiDVXJ8VI
Swimming bacteria sense chemicals in their environment and use this information to decide how to move—a sensory phenomenon known as chemotaxis. Central to their chemotactic ability, bacterial cells possess large clusters of sensory proteins termed chemosensory arrays. The chemosensory array integrates and interprets the many complex signals bacterial cells inevitably encounter and allow the organism to find food, avoid toxins, and exhibit other behaviors crucial to its survival. • This movie depicts a molecular dynamics simulation of the bacterial chemosensory array. Clusters of receptor proteins (red) bind chemicals and send signals down their elongated structures to the kinases (blue) below. An adaptor protein (green) assists with the signal transduction. The structure pictured was computationally derived from the synthesis of multi-scale experimental data from crystallography and electron microscopy. • Related paper: • Cassidy, C. Keith, Benjamin A. Himes, Frances J. Alvarez, Jun Ma, Gongpu Zhao, Juan R. Perilla, Klaus Schulten, and Peijun Zhang. CryoEM and computer simulations reveal a novel kinase conformational switch in bacterial chemotaxis signaling. eLife (2015): e08419. • LINK: http://elifesciences.org/content/earl... • Movie rendered using VMD. • Credit: C. Keith Cassidy • http://www.ks.uiuc.edu/~ccassid2/
#############################
