Youtor
ofloxacin
YOUR LINK HERE:
http://youtube.com/watch?v=POFkdyPghHk
Ofloxacin is a synthetic broad-spectrum antibiotic that belongs to the fluoroquinolone class. It is commonly used to treat a variety of bacterial infections. Here are some key points regarding its pharmaceutical chemistry: • Chemical Structure • Chemical Name: (±)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid. • Molecular Formula: C18H20FN3O4 • Molecular Weight: 361.37 g/mol • Structural Features: Ofloxacin contains a fluorine atom at position 6, a piperazine moiety at position 7, and a carboxylic acid group at position 3, which are characteristic of fluoroquinolones. • Mechanism of Action • Ofloxacin works by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes critical for DNA replication, transcription, repair, and recombination. This inhibition prevents the bacteria from reproducing and ultimately leads to cell death. • Pharmacokinetics • Absorption: Ofloxacin is well absorbed from the gastrointestinal tract with peak plasma concentrations occurring 1 to 2 hours after oral administration. • Distribution: It is widely distributed throughout the body, including tissues and fluids such as the prostate, lungs, and bile. • Metabolism: Ofloxacin is metabolized minimally in the liver. • Excretion: It is primarily excreted unchanged in the urine. • Therapeutic Uses • Ofloxacin is used to treat various bacterial infections, including: • Respiratory tract infections • Urinary tract infections • Skin and soft tissue infections • Prostatitis • Certain types of gastrointestinal infections • Adverse Effects • Common side effects include: • Gastrointestinal disturbances (nausea, vomiting, diarrhea) • Central nervous system effects (headache, dizziness, insomnia) • Skin reactions (rash, pruritus) • Tendonitis and tendon rupture (rare but significant) • Synthesis • The synthesis of ofloxacin involves multiple steps, starting with the preparation of the fluoroquinolone core structure, followed by the introduction of the piperazine ring and the carboxylic acid group. The process typically includes: • Cyclization to form the quinolone core. • Fluorination at the 6-position. • Introduction of the piperazine moiety. • Final modification to obtain the active pharmaceutical ingredient. • For creating a YouTube video tag for a video related to Ofloxacin and its pharmaceutical chemistry, it's important to use keywords that accurately describe the content and help viewers find the video easily. Here are some suggested tags: • Ofloxacin • Fluoroquinolone • Antibiotics • Bacterial infections • Pharmaceutical chemistry • DNA gyrase inhibitor • Topoisomerase IV inhibitor • Antibiotic mechanism of action • Ofloxacin synthesis • Ofloxacin pharmacokinetics • Ofloxacin side effects • Ofloxacin uses • Respiratory tract infections treatment • Urinary tract infections treatment • Antibiotic resistance • Broad-spectrum antibiotic • Medical microbiology • Drug formulation • Medicinal chemistry • Clinical 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