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Biochemistry Chapter Genes DNA Underwinding Episode08 Basic Science Series
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Biochemistry | Chapter- Genes | DNA Underwinding | Strand Separation | Episode-08 | Basic Science Series • DNA underwinding, Biochemistry of DNA, Gene structure and function, Supercoiling in DNA, Strand separation mechanisms, DNA topology, DNA helicases, DNA replication process, DNA supercoiling regulation, Topoisomerases and DNA unwinding, Nucleic acid structure, DNA double helix, Chromatin organization, DNA gyrase, DNA damage and repair, DNA recombination, Transcription and DNA strand separation, DNA replication fork, DNA melting, DNA secondary structure, DNA denaturation, DNA-binding proteins, DNA topoisomerase inhibitors, DNA supercoiling and gene expression, DNA unwinding during transcription, DNA topoisomerase mechanisms, DNA topoisomerase inhibitors in cancer therapy, DNA supercoiling and chromosomal condensation, DNA topology and DNA-protein interactions, DNA supercoiling and DNA packaging. • DNA underwinding refers to the process of reducing the number of twists or turns in the DNA double helix structure. Normally, DNA exists in a tightly wound state with a specific number of twists per unit length. However, under certain conditions, such as during DNA replication, transcription, or DNA-protein interactions, the DNA helix can become underwound. • Underwinding of DNA occurs when the helical structure of DNA is relaxed or when the number of twists decreases below the normal level. This can result in a decrease in the number of base pairs per helical turn. As a consequence, the double helix becomes more open and less tightly coiled. • DNA underwinding plays a crucial role in various biological processes. For example, it facilitates the separation of DNA strands during replication and transcription by reducing the energy required to unwind the DNA helix. It also affects the accessibility of DNA to various proteins involved in gene expression and regulation. • Topoisomerases, a class of enzymes, actively participate in the regulation of DNA underwinding. They can introduce or remove twists in the DNA molecule, helping to maintain the appropriate level of DNA supercoiling and preventing excessive underwinding or overwinding. • Overall, DNA underwinding is an essential aspect of DNA structure and function, influencing processes such as replication, transcription, and DNA-protein interactions. • • WhatsApp group: https://chat.whatsapp.com/HTXQC1Ax2qf... • Twitter: / basic_series • Facebook Group: / 742235929758671 • LinkedIn: / basic-science-series-a54439208 • Instagram: / basic_science_series • Support my work at https://www.patreon.com/user?u=37177596 • Disclaimer: The information provided is for educational purposes only. The content of this channel should not be considered as medical advice of any kind. Use this information at your own risk. We hold no responsibility for any issue, concerns, or damage arising from the content of the video. Under no circumstances this channel be responsible or liable in any way for any content, including but not limited to, any errors or omissions in the content, any loss, any damage of any kind incurred as a result of any content communicated in this video, whether by this channel or a third party. In no event shall this channel be liable for any special indirect or consequential damages of any damages whatsoever resulting from the content of the channel.
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