Conférence E CHARPENTIER Le CRISPR Cas9 La révolution de lingénierie génomique

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Conférence de Emmanuelle CHARPENTIER intitulée The CRISPR-Cas9 revolution in genome engineering: lessons learned from bacteria • 00:00:00 Introduction • 00:01:10 Understand diseases at the fundamental level • 00:04:16 Jacques Monod (1910-1976) • 00:05:30 Important milestones towards gene therapy • 00:10:09 The CRISPR craze • 00:10:56 Bacterial pathogens • 00:11:26 Understand bacteria/host interactions • 00:11:52 Infection of bacteria by invading genomes • 00:14:14 The CRISPR-Cas adaptive immune system • 00:17:37 - Spacer acquisition • 00:19:04 - crRNA expression and maturation • 00:20:06 - interference • 00:23:01 - mecanisms • 00:23:06 CRISPR-Cas has evolved into five major types • 00:24:02 Sans titre • 00:26:19 CRISPR-Cas9 technology: a two-component system • 00:29:04 CRISPR-Cas9 pathway in bacteria • 00:29:09 Type II CRISPR-Cas locus • 00:29:30 Type II CRISPR-Cas: model of crRNA maturation • 00:30:22 Type II CRISPR-Cas: model of DNA targeting • 00:30:38 Type II CRISPR-Cas • 00:30:40 CRISPR-Cas9: RNA-programmable DNA cleavage • 00:31:08 Genome editing with sequence-specific nucleases • 00:31:54 The CRISPR-Cas9 technology • 00:34:01 Cas9 toolbox • 00:34:17 tracrRNA is associated to type II CRISPR-Cas • 00:34:46 Applications of CRISPR-Cas9 in biology • 00:34:54 Applications of CRISPR-Cas9 in human medicine • 00:37:10 CRISPR-Cas9: funding • 00:37:24 CRISPR-Cas9: people • 00:39:01 The Lab • 00:39:08 Thank you • 00:39:33 Questions • • © Académie des sciences - Tous droits réservés

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