OrexinHypocretin Role In Sleep And Narcolepsy Explained Sleep Neuroscience Originals

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Welcome to Science With Tal! • In this video, we will cover some basic sleep physiology, what where orexin neurons are as well as what function do they mediate. We will also consider some clinical implications of orexin signaling and how it relates to sleep disorders such as narcolepsy and insomnia • To improve the quality of my content, I highly value the feedback from the viewer so do not hesitate to give any feedback in the comment section. • TIMESTAMPS • 0:00 Introduction • 0:50 Polysomnogram Hypnogram • 2:54 Sleep Circuit In Brain (Wake/Sleep-Promoting) • 4:40 Molecular Mechanism Of Orexin • 6:00 Orexin Influence On Sleep Circuit • 6:51 Orexin Narcolepsy • 8:14 Orexin Insomnia • 9:04 Conclusion • RESOURCES • Here is a list of the resources that I’ve used to produce this video. (Author(s): title resource) • Eric Kandel: Principles of neural science (6th edition) • Meir Kryger: Principles and practice of sleep medicine (7th edition) • Ayumu Inutsuka: The physiological role of orexin/hypocretin neurons in the regulation of sleep/wakefulness and neuroendocrine functions • Timothy Quinnell: Narcolepsy, idiopathic hypersomnolence and related conditions • Chunmei Wang: The Orexin/Receptor System: Molecular Mechanism and Therapeutic Potential for Neurological Diseases • To have more information on these resources, you can refer to the conclusion section where a more formal citation is provided. • CREDITS • Writing: Tal Klimenko • Voice: Tal Klimenko • Animations: Tal Klimenko • Drawings: Tal Klimenko • Editing: Tal Klimenko • Introductory jingle: Thierry Du Sablond • Conclusion music: lukrembo - sunflower ( • lukrembo - sunflower (royalty free vl... )

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