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PHARMACOLOGY OF Bimatoprost Lumigan Latisse Overview Pharmacokinetics Uses Mechanism of action
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Bimatoprost is a prostaglandin F2α analogue used primarily to treat elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension. It is also used cosmetically to enhance eyelash growth. Here's an overview of its pharmacology: • Mechanism of Action: • Prostaglandin F2α Receptor Agonist: Bimatoprost is a selective full agonist for the prostaglandin FP receptor. By activating this receptor, it increases the outflow of aqueous humor through both the trabecular meshwork and the uveoscleral pathways, thereby reducing intraocular pressure. • Pharmacokinetics: • Absorption: Bimatoprost is administered as an eye drop and is rapidly absorbed through the cornea. • Distribution: It is distributed throughout the eye, with peak concentrations achieved within 2 hours of administration. • Metabolism: Bimatoprost is hydrolyzed by esterases in the cornea to its active free acid form. • Excretion: The drug and its metabolites are excreted primarily via the kidneys. • Elimination Half-Life: The terminal elimination half-life is approximately 17 minutes in aqueous fluid and 1.5 hours overall. • Clinical Use: • Glaucoma Treatment: Bimatoprost is used to reduce elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension. • Cosmetic Use: It is also used to enhance eyelash growth in patients with hypotrichosis (sparse eyelashes). • Side Effects: • Common Side Effects: Red eyes, blurry vision, eye pain, dry eyes, and change in color of the eyes. • Serious Side Effects: Permanent darkening of eyelashes, darkening of the iris to brown (heterochromia), and inflammation of the prostate gland (in males) • #Bimatoprost
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