EasytoGrasp Explanations 5FU 5Fluorouracil updated

>> YOUR LINK HERE: ___ http://youtube.com/watch?v=SY7g7OcEu_g

Join Dr. Chat Perche, MD, PhD, for a high-speed study session. • This video is designed so that by the time you finish watching, you'll have perfectly memorized the frequently asked exam topics. • By the end of this video, you'll have perfectly memorized about 5-FU. • It masquerades as Uracil, and induces damage to DNA. • Do you want to know the mechanism of action? • Elevate your understanding of 5-Fluorouracil (5-FU) with my updated YouTube video! 🎥🔬 • In this enhanced version, I provide a deeper exploration of 5-FU as a pyrimidine analogue disrupting DNA synthesis. • Ace your exams by understanding the core concepts without unnecessary complexities. Watch now and boost your knowledge efficiently! 📚✨ • #5FU #pharmacologylectures #anticancer • 【Notes】 • ▹This video was created based on data as of January 2024, with the purpose of supporting medical students in their exam preparations. • ▹Please note that thanks to the tireless efforts of researchers worldwide, this data is updated daily. ▹Unauthorized reproduction is prohibited. • 【Contents】 • 00:00 5-FU: an antimetabolite that mimics uracil • 01:20 5-FU: the mechanism of action, operating as a mimic, emulating the functions of uracil. • 02:58 5-FU funcitions in S phase of cell cycle. • 【Reference and figure】　I express my gratitude and respect for your wonderful achievements. • 1. Longley, D., Harkin, D. Johnston, P. 5-Fluorouracil: mechanisms of action and clinical strategies. Nat Rev Cancer 3, 330–338 (2003). https://doi.org/10.1038/nrc1074 • 2. Chen D, Jansson A, Sim D, Larsson A, Nordlund P. Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states. J Biol Chem. 2017 Aug 11;292(32):13449-13458. doi: 10.1074/jbc.M117.787267. Epub 2017 Jun 20. PMID: 28634233; PMCID: PMC5555203. • 3. Jagdish Chander, Harmanjit Singh, Dinesh Joshi, 7.24 - 5-Flucytosine, Editor(s): Terry Kenakin, Comprehensive Pharmacology, Elsevier, 2022, Pages 384-392, ISBN 9780128208762, https://doi.org/10.1016/B978-0-12-820.... (https://www.sciencedirect.com/science...)

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