Youtor
Pathogenesis of Amoebiasis Step by Step to How You get Infected
>> YOUR LINK HERE: ___ http://youtube.com/watch?v=TbdfFIPsC0I
The pathogenesis of amoebiasis involves several stages, starting from the ingestion of the infectious cysts to the invasion of host tissues by the trophozoites. Here's a detailed overview: • 1. Ingestion of Cysts: • Transmission: The infection is primarily transmitted through the fecal-oral route, often via contaminated food or water. • Cysts: The infective stage of the parasite, Entamoeba histolytica, is the cyst, which is resistant to environmental conditions and can survive outside the host for weeks to months. • 2. Excystation: • Colon: Once ingested, the cysts reach the colon, where they undergo excystation to release trophozoites. • Trophozoites: These are the active, motile form of the parasite that can invade the colonic mucosa. • 3. Invasion of Colonic Mucosa: • Tissue Destruction: Trophozoites invade the colonic mucosa, leading to tissue destruction and inflammation. • Secretory Diarrhea: The invasion causes secretory diarrhea, which can be bloody due to the damage to the intestinal lining. • 4. Spread to Other Organs: • Hematogenous Spread: Trophozoites can enter the bloodstream and spread to other organs, most commonly the liver. • Liver Abscess: In the liver, they can form abscesses, which are collections of pus. • 5. Immune Response: • Inflammation: The body's immune response to the infection can cause further tissue damage and inflammation. • Chronic Infection: In some cases, the infection can become chronic, leading to long-term complications. • 6. Asymptomatic Carriers: • Cysts in Stool: Some individuals may carry the parasite without showing symptoms, shedding cysts in their stool and potentially spreading the infection to others. • 7. Complications: • Intestinal Perforation: Severe cases can lead to perforation of the colon, causing peritonitis. • Other Organ Involvement: Rarely, the infection can spread to other organs such as the lungs, brain, and spleen. • Understanding the pathogenesis of amoebiasis is crucial for effective diagnosis, treatment, and prevention of the disease. If you have any specific questions or need more details, feel free to ask! • #Amoebiasis
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