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Glucose-6-phosphate dehydrogenase deficiency, also known as favism, is the most common enzyme deficiency anemia worldwide. It is an inborn error of metabolism that predisposes to red blood cell breakdown. Most of the time, those who are affected have no symptoms. • Symptoms: Yellowish skin, dark urine, shortness of breath • Treatment: Avoiding triggers, medications for infection, stopping offending medication, blood transfusions • Complications: Anemia, newborn jaundice • Deaths: 33,000 (2015) • Diagnostic method: Based on symptoms, blood test, genetic testing • Differential diagnosis: Pyruvate kinase deficiency, hereditary spherocytosis, sickle cell anemia • Frequency: 400 million • #g6pd #
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