Molecular Chaperones Guardians of Tumor Suppressor Stability Oncotarget

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Oncotarget #published this #trending review on October 1, 2024 in Volume 15, entitled, “Molecular chaperones: Guardians of tumor suppressor stability and function” by researchers from the Department of Urology, SUNY Upstate Medical University, Syracuse, NY; Upstate Cancer Center, SUNY Upstate Medical University, Syracuse, NY; Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY; Syracuse VA Medical Center, New York VA Health Care, Syracuse, NY. ‪@UpstateMedicalUniv‬ • #cancer #tumor #rcc #kidneycancer #review #openaccess #openscience #peerreview #journal #publication #publishing #meded • DOI - https://doi.org/10.18632/oncotarget.2... • Correspondence to - Mehdi Mollapour - [email protected] • Abstract • The term ‘tumor suppressor’ describes a widely diverse set of genes that are generally involved in the suppression of metastasis, but lead to tumorigenesis upon loss-of-function mutations. Despite the protein products of tumor suppressors exhibiting drastically different structures and functions, many share a common regulatory mechanism—they are molecular chaperone ‘clients’. Clients of molecular chaperones depend on an intracellular network of chaperones and co-chaperones to maintain stability. Mutations of tumor suppressors that disrupt proper chaperoning prevent the cell from maintaining sufficient protein levels for physiological function. This review discusses the role of the molecular chaperones Hsp70 and Hsp90 in maintaining the stability and functional integrity of tumor suppressors. The contribution of cochaperones prefoldin, HOP, Aha1, p23, FNIP1/2 and Tsc1 as well as the chaperonin TRiC to tumor suppressor stability is also discussed. Genes implicated in renal cell carcinoma development—VHL, TSC1/2, and FLCN—will be used as examples to explore this concept, as well as how pathogenic mutations of tumor suppressors cause disease by disrupting protein chaperoning, maturation, and function. • Sign up for free Altmetric alerts about this article: https://oncotarget.altmetric.com/deta... • Subscribe for free publication alerts from Oncotarget: • https://www.oncotarget.com/subscribe/ • Keywords - cancer, molecular chaperone, tumor suppressor, renal cell carcinoma, Birt-Hogg-Dubé (BHD) syndrome, TSC syndrome • About Oncotarget • Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. • Oncotarget is indexed and archived by PubMed/Medline, PubMed Central, Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science). • To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: • Facebook - / oncotarget • X - / oncotarget • Instagram - / oncotargetjrnl • YouTube - / @oncotargetjournal • LinkedIn - / oncotarget • Pinterest - / oncotarget • Reddit - / oncotarget • Spotify - https://open.spotify.com/show/0gRwT6B... • Media Contact • [email protected] • 18009220957

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