Pharmacology ANTICOAGULANTS amp ANTIPLATELET DRUGS MADE EASY

>> YOUR LINK HERE: ___ http://youtube.com/watch?v=V5kA49D4I8Y

Prasugrel is an antiplatelet medication used to reduce the risk of thrombotic cardiovascular events in patients with acute coronary syndrome (ACS). Here's a brief overview of its pharmacology: • Mechanism of Action • Prasugrel is a prodrug that requires hepatic metabolism to its active form. The active metabolite irreversibly binds to the P2Y12 adenosine diphosphate (ADP) receptor on platelets, inhibiting platelet aggregation for the life of the platelet. This helps to prevent blood clots from forming. • Administration Routes • Prasugrel is administered orally. • Pharmacokinetics • Absorption: Prasugrel has a bioavailability of approximately 79%. • Distribution: It is 98% protein-bound. • Metabolism: Metabolized in the liver by CYP3A4 and CYP2B6. • Excretion: Excreted mainly through urine (68%) and to a lesser extent through feces (27%). • Half-Life: The elimination half-life is about 7 hours (range 2-15 hours). • Indications • Prasugrel is indicated for the treatment of ACS in patients who are to be managed with percutaneous coronary intervention (PCI). It is used in combination with low-dose aspirin to prevent thrombosis. • Adverse Effects • Common side effects include: • Bleeding (including fatal and intracranial bleeding) • Headache • Nausea • Diarrhea • More serious side effects can include: • Severe bleeding • Hypersensitivity reactions • Prasugrel is not recommended for patients who are 75 years or older, those with a history of stroke or transient ischemic attack, or those who weigh less than 60 kg due to an increased risk of bleeding. • Does this cover what you were looking for, or is there something more specific you'd like to know about prasugrel? • #Prasugrel

#############################

New on site