Heparin Mnemonic for USMLE

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Study this Heparin mnemonic and other mnemonics with Pixorize. • Heparin is an anticoagulant drug used to prevent blood clotting in a variety of different clinical contexts. Heparin works by activating antithrombin, which then goes on to inhibit several clotting factors. Namely, the activated forms of factors 2 and 10 are inhibited. This leads to anticoagulation, which is measured or monitored by an elevation of PTT. In contrast to other anticoagulants, Heparin is considered to be safe to use during pregnancy. Potential side effects of heparin include excessive bleeding, and Heparin Induced Thrombocytopenia, or HIT. In HIT, antibodies are produced against a heparin-platelet-factor four complex. This activates platelets, causing a pro-thrombotic state that consumes or uses up platelets while reducing platelet counts. Importantly, heparin’s effects can be reversed by administering protamine sulfate. • Subscribe for more: https://bit.ly/2yybxhm • Study interactive image: https://pixorize.com/view/6307 • #USMLE #Step1 #Pharm #heparin #bloodclot • 0:00 Introduction • 0:28 Heparin (hairpin) • 0:59 Activates Antithrombin • 1:47 Inhibits Factor Ila / Thrombin (broken 2 buck-teeth - Factor II) • 2:51 Inhibits Factor Xa • 3:28 Anticoagulant (splattered red cake) • 3:58 Elevated PTT • 5:31 Safe for Pregnancy (laughing pregnant mom) • 5:58 Bleeding (bleeding foot) • 6:33 Heparin-Induced Thrombocytopenia via Anti-PF4 (broken plates, door 4) • 8:08 Reverse with Protamine (Pro-team jersey)

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