Erythema Multiforme Etiology Clinical features Histopathology treatment
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Aphthous ulcers also called recurrent aphthous stomatitis (RAS) or simply known as canker sore is a common ulcerative inflammatory condition of the oral cavity. The reported prevalence in the general population varies between 5% to 66%. It typically starts in childhood or adolescence as small recurrent, painful, round, or ovoid ulcers with well-defined erythematous margins, and a central yellow or gray floor. • The lesions have a recurrent nature meaning that they are episodic once they appear for the first time in an individual’s mouth. • The exact cause or etiopathogenesis for aphthous ulcers (canker sores) is unknown, however, it’s thought that ulceration might result from a sudden activation of the cell-mediated immune system at the site of ulceration leading to the liberation of cell signaling molecules or cytokines like TNF-alpha and some other interleukins. These cytokines cause antigen expression on oral epithelial cells. The oral epithelial cells are then recognized by T lymphocytes which then trigger a cytotoxic response and the epithelial cells are phagocytized by immune cells resulting in ulceration. • Some known triggers can cause the stimulation of such an immune response • Video (diagrams+editing) Voiceover: • Dr.Maryam Kazman • Become a Patreon and Get Exclusive Rewards: • / dentalmaniak • Join me on facebook: • / dentalmaniak. . • instagram: / dentalmaniak
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