Autophagy a Key for Longevity health aging longevity spermidine autophagy diet liver fat

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The original presentation is available for download as a PDF file from the link: • https://drive.google.com/file/d/1Pl8N... • https://drive.google.com/file/d/12EYt... • Компьютерный перевод текста презентации на русский язык также доступен для скачивания по ссылке: • https://drive.google.com/file/d/1AZ7M... • Join my Telegram channel: https://t.me/OlegKulikov to communicate with me • Join your health longevity group: https://t.me/+PbE43EFvEFRjYzU9 • If you think humans deserve to live a long, healthy, and productive life and have a galactic future, you may support my project: https://buymeacoffee.com/drolegkulikov • You can personally join my project with Patreon: (https://paypal.me/drolegkulikov?count.... • or make donations through PayPal: (https://www.paypal.me/IrinaDumic). • Don’t hesitate to contact me with proposals and questions by email ([email protected]). • In return for your support, I am offering exclusive access to all my materials and presentations, early access to uploaded presentations and videos, and my answers to your questions, if you have any. • Also, subscribe to my channel, share this information with your friends and relatives, and click on a bell button to get notifications on the new content. • I am not a medical professional but a Dr. in science and have a PhD in physics and math. While I rely on thorough research of scientific literature and practical experience for personal benefit, I recognize that what works for me may not work for others. Therefore, I don't offer medical advice, but I hope the information and links provided can help others make informed decisions. The use of information on this YouTube channel or materials linked to my project is at the user’s own risk. • Autophagy is a key process in cellular health and longevity, involving the breakdown and recycling of damaged organelles and proteins. Regular activation of autophagy, which can be induced through fasting and spermidine supplementation, helps reduce inflammation, regulate lipid metabolism, and improve mitochondrial health. Spermidine, a naturally occurring polyamine, has been found to promote autophagy, reduce inflammation and oxidative stress, and protect against age-related diseases. With age, autophagy declines, partly due to lower levels of spermidine, especially in the immune system. This reduction in autophagy contributes to aging and health issues. • Both fasting and spermidine work by activating longevity pathways like AMPK and inhibiting mTOR, a nutrient-sensing pathway that accelerates aging when overactive. Fasting reduces chronic inflammation (inflammaging), which is a major factor in aging, and spermidine has similar anti-inflammatory effects. Spermidine also enhances mitochondrial health through mitophagy, the selective degradation of damaged mitochondria, improving energy efficiency, and reducing oxidative stress. Moreover, fasting and spermidine work synergistically, amplifying each other's anti-aging benefits. • Spermidine supplementation has been linked to increased lifespan in humans as well as extended health span in animals. Studies suggest that long-term spermidine intake can protect cardiovascular health, lower blood pressure, and delay the onset of cardiovascular disease. It also helps prevent kidney damage related to hypertension and has been found to reduce cardiac hypertrophy in aging mice. In humans, higher dietary spermidine intake correlates with reduced mortality and better cardiovascular outcomes. • Dietary sources of spermidine, such as aged cheeses, mushrooms, and organ meats, can significantly contribute to longevity. However, cooking methods can impact polyamine content, with certain methods like grilling or boiling reducing levels, while sous vide and microwave cooking preserve these vital compounds. Including these foods in a diet, especially in combination with fasting, can maximize the benefits of autophagy and improve overall health. • Mushrooms, in particular, are not only rich in spermidine but also contain other bioactive compounds such as chitin, which has prebiotic effects that stimulate the growth of beneficial gut microbiota and inhibit pathogens. Chitin and its derivative, chitosan, have been shown to possess various health-promoting properties, including anti-inflammatory, antioxidant, and antimicrobial effects. They also contribute to better glucose tolerance, insulin secretion, and lipid metabolism, making them beneficial for metabolic health and longevity. • To achieve optimal longevity, it is essential to maintain a ketogenic diet, practice intermittent fasting, and consume nutrient-dense foods such as organ meats, eggs, and whey protein concentrate. By promoting autophagy, reducing inflammation, and supporting mitochondrial function, these interventions can help protect against age-related diseases and improve health.

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