Vitamin B12 Deficiency USMLE Biochemistry Case based discussion

>> YOUR LINK HERE: ___ http://youtube.com/watch?v=ZAfL7qomaZ0

📌 𝐅𝐨𝐥𝐥𝐨𝐰 𝐨𝐧 𝐈𝐧𝐬𝐭𝐚𝐠𝐫𝐚𝐦:- / drgbhanuprakash • 📌𝗝𝗼𝗶𝗻 𝗢𝘂𝗿 𝗧𝗲𝗹𝗲𝗴𝗿𝗮𝗺 𝗖𝗵𝗮𝗻𝗻𝗲𝗹 𝗛𝗲𝗿𝗲:- https://t.me/bhanuprakashdr • 📌𝗦𝘂𝗯𝘀𝗰𝗿𝗶𝗯𝗲 𝗧𝗼 𝗠𝘆 𝗠𝗮𝗶𝗹𝗶𝗻𝗴 𝗟𝗶𝘀𝘁:- https://linktr.ee/DrGBhanuprakash • Patients classically present with megaloblastic anemia, atrophic glossitis, neurological changes characterized by symmetrical lower extremity neuropathy that is greater than upper extremity neuropathy with paresthesias and ataxia that may progress to weakness and spasticity, cerebellar ataxia, and personality changes. Concomitant folate deficiency is often present and may mimic many symptoms of B12 deficiency. • Vitamin B12, or cobalamin, is a water-soluble vitamin found in meat, fish, and dairy products and, once combined with intrinsic factor in the stomach, is absorbed in the ileum. Patients at risk for B12 deficiency include those with a lack of intrinsic factor (pernicious anemia) or antibodies to intrinsic factor, patients with malabsorption syndromes, especially those who have had a gastrectomy, gastric bypass, or chronic pancreatitis, or those with infections such as Helicobacter pylori or tapeworm infections. In addition, strict vegans, alcoholics, and older adults are particularly vulnerable to B12 deficiency.

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