Pharmacology of Mebendazole Vermox Definition Uses Mechanism of action Side effects

>> YOUR LINK HERE: ___ http://youtube.com/watch?v=ZnYsWA7cfFU

Mebendazole is an anthelmintic medication. • • Classification: • • 1. Anthelmintic (benzimidazole derivative) • • Mechanism of Action: • • 1. Binds to β-tubulin, disrupting microtubule assembly. • 2. Inhibits glucose uptake, depleting parasite energy. • • Indications: • • 1. Hookworm infections • 2. Roundworm infections • 3. Whipworm infections • 4. Pinworm infections • 5. Intestinal worm infections • • Pharmacokinetics: • • 1. Oral bioavailability: 20-40% • 2. Peak plasma concentration: 2-4 hours • 3. Half-life: 2-9 hours • 4. Metabolism: Hepatic (CYP1A2, CYP2C19) • 5. Excretion: Urine (primary route), feces • • Dosage and Administration: • • 1. Oral tablets or suspension • 2. Adult dose: • Hookworm/roundworm/whipworm: 100 mg twice daily for 3 days • Pinworm: 100 mg single dose, repeat in 2 weeks • • Adverse Effects: • • 1. Gastrointestinal: nausea, vomiting, diarrhea • 2. Abdominal pain • 3. Headache • 4. Dizziness • • Contraindications: • • 1. Hypersensitivity to mebendazole or benzimidazoles • 2. Pregnancy (especially during first trimester) • 3. Lactation • • Interactions: • • 1. Theophylline: increased theophylline levels • 2. Carbamazepine: decreased carbamazepine levels • 3. Cimetidine: increased mebendazole levels • #Mebendazole

#############################

New on site