Actin Binding Proteins ABP Cell Proteins and Cell Filaments

>> YOUR LINK HERE: ___ http://youtube.com/watch?v=ZzKNM-rLv6k

I've just finished creating this incredible video all about actin, and I couldn't wait to share all the fascinating things I've explained, with you. So, let's dive into this cell biology video and explore the captivating world of Actin and its role in our bodies! • ▬ 📜 Actin – Structure ▬▬▬▬▬▬▬▬▬▬ • Actin is like a superstar in the world of proteins. It's an essential component of our cells, working tirelessly behind the scenes to carry out various functions. Picture it as a versatile actor, playing different roles depending on what the cell needs. • Actin has a unique structure. It can exist in two forms: • 🟤 G-actin (Globular Actin) • 🟤 F-actin (Filamentous Actin) • G-actin is like the cool, laid-back version, while F-actin is the more energetic, show-stopping one. • When G-actin molecules come together, they form long chains called actin filaments or microfilaments. These filaments are like the backbone of the cell, providing structural support and giving it the ability to move and change shape. • Actin folds into two domains, an outer domain and an inner domain, with an adenine nucleotide nestled in between. This setup stabilizes the domains. These domains are further divided into subdomains, 2 each. This means there are a total of 4 subdomains of actin. • 🟠 Subdomain 1 • 🟠 Subdomain 2 • 🟠 Subdomain 3 • 🟠 Subdomain 4 • 👉 Actin – Microfilaments • Now, let's talk about the stage where actin truly shines—the actin filament itself. It has distinct ends: • 🟤 Barbed End (Plus End) • 🟤 Pointed End (Pointed End) • Think of the barbed end as the entrance, where actin can add more molecules to grow the filament, and the pointed end as the exit, where molecules can leave. • This creates a fascinating phenomenon called treadmilling, where actin is continuously being added at one end while being removed at the other, giving the filament a dynamic and ever-changing nature. • You can learn about how G-actin polymerizes to F-actin, in the actin polymerization video of this collection. • Actin – Isoforms • Actin, being the superstar it is, doesn't settle for just one form. It has different isoforms, each with its own special talents. These isoforms add diversity to actin's performances, allowing it to adapt to various cellular functions. • In humans, there are six isoforms of actin. • These include: • 🔵 β and γ isoforms in Non-Muscle Cells. • 🔵 Four Different α and β isoforms in Muscle Cells. • Red blood cells have their favorite β-actin all the way. • ▬ 📜 Actin – Function ▬▬▬▬▬▬▬▬▬▬ • In muscle cells, Actin steals the spotlight, showing off its contractile function. • But, when it comes to non-muscle cells, Actin is a multitasking superstar! • In non-muscle cells, it: • 🟡 Maintains the structure of microvilli. • 🟡 A key player in the terminal web. • 🟡 Enables macrophages to move with style through gel-sol transitions of the Actin network. • 🟡 Facilitates the movement of fibroblasts and nerve growth cones. • ▬ 📜 Actin -binding Proteins (ABPs) ▬▬▬▬▬▬▬▬▬▬ • In this actin show, there are also some important supporting actors. • Profilin, for instance, assists actin by promoting its polymerization, helping it grow and become a stronger performer. Tropomyosin steps in as a regulator, controlling actin's interaction with other proteins and determining its function. • But wait, there's more! • Cofilin takes on the role of actin's partner in crime, promoting actin depolymerization, or the breakdown of the actin filament. • Thymosin, on the other hand, keeps actin in check, preventing it from polymerizing when it's not needed. • Now, imagine actin as the director of the show, giving instructions to its supporting actors. • Formin, ARP complex, capping protein, Gelsolin, Fimbrin, and α-Actinin - all play crucial roles in actin's performances, shaping the actin filament and regulating its behavior. • So, Guys! Actin is no ordinary protein—it's a star! • With its actin-binding protein buddies, it creates a dynamic and ever-changing show within our cells. From its unique structure to its diverse isoforms, actin's performances are truly captivating. • So, next time you see actin in action, remember the incredible story it tells and the vital role it plays in our bodies. • It's a show you won't want to miss! • #cellbiology #cellcycle #cellularprocesses #cellbiologycsirnetlifescience #cellorganelle #cellorganelles

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