L23 Granulocytes and Agranulocytes An introduction
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#biotechnology #immunology #immunecells #whitebloodcells • Granulocytes, Agranulocytes • This is the third video in the series and is a quick overview of the Granulocytes and Agranulocytes. The links to the first two videos are the following • L2.1: Immunology; Hematopoiesis; Hematopoietic Stem Cell and Common Myeloid-Erythroid Progenitor • • L21: Hematopoiesis; Hematopoietic Ste... • L2.2: Immunology; Hematopoiesis; Hematopoietic Stem Cell (HSC) and Common Lymphoid Progenitor • • L22: Hematopoiesis; Hematopoietic Ste... • Granulocytes and agranulocytes are two main types of white blood cells (leukocytes) that play crucial roles in the immune system. They are distinguished based on the presence or absence of granules in their cytoplasm and have different functions in defending the body against infections. • Granulocytes • Granulocytes have granules or small particles in their cytoplasm that contain enzymes and other substances involved in immune responses. There are three main types of granulocytes: • Neutrophils • Most abundant type of white blood cells. • Play a key role in the initial defense against bacterial infections. • Engulf and digest bacteria through a process called phagocytosis. • Eosinophils • Involved in allergic reactions and parasitic infections. • Release enzymes that combat the effects of histamines and other inflammatory substances. • Basophils • Release histamine and other chemicals during inflammatory reactions. • Play a role in allergic responses. • Agranulocytes • Agranulocytes do not have visible granules in their cytoplasm. There are two main types of agranulocytes: • Lymphocytes • Key components of the immune system. • There are two main types: B cells and T cells. • B cells produce antibodies to neutralize pathogens, while T cells have various roles, including directly attacking infected cells and coordinating immune responses. • Monocytes • The largest type of white blood cells. • Play a role in the immune response by phagocytosis. • Monocytes can migrate into tissues and differentiate into macrophages, which are effective in engulfing and digesting pathogens. • Functions • Granulocytes: Primarily involved in the innate immune response, providing immediate, non-specific defense against infections. • Agranulocytes (Lymphocytes and Monocytes): Play a crucial role in adaptive immune responses, providing targeted and specific defense against pathogens. • Summary • Granulocytes: Neutrophils, Eosinophils, Basophils (involved in non-specific defense). • Agranulocytes: Lymphocytes (B cells, T cells) and Monocytes (involved in specific immune responses). • Understanding the distinctions between granulocytes and agranulocytes is fundamental to comprehending the complexity and efficiency of the immune system in protecting the body from various pathogens and maintaining overall health.
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