Colchicine in Dermatology Agent Mechanism of Action Uses Sideeffects

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#immunosuppression #immunomodulator #colchicine # dapsone • Hi. With this video, we will discuss the use of Colchicine in Dermatology and be better prepared for treating our patients. This video is directed towards dermatologists and is not at all advisory for non-medical personnel. • Introduction - 01:30 • Pharmacology - 05:45 • Mechanism of Action - 10:06 • Mechanism of Action: Anti-Inflammatory - 14:14 • Uses: Chronic Urticaria - 21:07 • Uses: Cutaneous Vasculitis - 22:33 • Uses: Neutrophilic Disorders - 23:29 • Uses: Neutrophilic Bullous Disorders - 25:53 • Uses: Others - 27:47 • Adverse Effects - 31:23 • Drug Interactions - 33:31 • Dose Reductions - 35:08 • Toxicity - 36:17 • Pregnancy - 40:40 • Further Reading - 41:40 • End - 43:15 • Good articles on Colchicine: • 1. Colchicine; product insert. https://www.accessdata.fda.gov/drugsa... • 2. Robinson KP, Chan JJ. Colchicine in dermatology: A review. Australas J Dermatol. 2018 Nov;59(4):278-285. doi: 10.1111/ajd.12795. Epub 2018 Feb 12. PMID: 29430631. • 3. Dastoli S, Nisticò SP, Morrone P, Patruno C, Leo A, Citraro R, Gallelli L, Russo E, De Sarro G, Bennardo L. Colchicine in Managing Skin Conditions: A Systematic Review. Pharmaceutics. 2022 Jan 27;14(2):294. doi: 10.3390/pharmaceutics14020294. PMID: 35214027; PMCID: PMC8878049. • 4. Leung YY, Yao Hui LL, Kraus VB. Colchicine--Update on mechanisms of action and therapeutic uses. Semin Arthritis Rheum. 2015 Dec;45(3):341-50. doi: 10.1016/j.semarthrit.2015.06.013. Epub 2015 Jun 26. PMID: 26228647; PMCID: PMC4656054. • 5. Cimmino G, Loffredo FS, De Rosa G, Cirillo P. Colchicine in Athero-Thrombosis: Molecular Mechanisms and Clinical Evidence. Int J Mol Sci. 2023 Jan 27;24(3):2483. doi: 10.3390/ijms24032483. PMID: 36768804; PMCID: PMC9917272.

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