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Do you know how Antidepressants work
>> YOUR LINK HERE: ___ http://youtube.com/watch?v=dDFuM15VolE
Learn about the mechanisms behind SSRIs, SNRIs, TCAs, and MAOIs, and understand the science of neurotransmitters like serotonin and norepinephrine. #antidepressants #pharmacology #usmlepreparation • 【Notes】 • ▹This video was created based on data as of July 2024, with the purpose of supporting medical students in their exam preparations. • ▹It is not a substitute for medical advice. • ▹Please note that thanks to the tireless efforts of researchers worldwide, this data is updated daily. ▹Unauthorized reproduction is prohibited. • 【Contents】 • 00:00 Antidepressants? • 00:12 The Chemical Imbalance Theory • 01:44 SSRIs and Reuptake: How Antidepressants Work • 03:53 SNRIs: Beyond Mood Improvement • 04:56 Tricyclic Antidepressants (TCAs): Broad Effects? • 06:54 Monoamine Oxidase and MAOIs: From TB to Antidepressants • 09:17 Chemical imbalance Theory? • 【Reference and figure】 I express my gratitude and respect for your wonderful achievements. • 1. López-Muñoz F, Alamo C. Monoaminergic neurotransmission: the history of the discovery of antidepressants from 1950s until today. Curr Pharm Des. 2009;15(14):1563-86. doi: 10.2174/138161209788168001. PMID: 19442174. • 2. Kálmán Magyar, The pharmacology of selegiline, Editor(s): Moussa B.H. Youdim, Peter Douce, International Review of Neurobiology, Academic Press, Volume 100, 2011, Pages 65-84, ISSN 0074-7742, ISBN 9780123864673, • https://doi.org/10.1016/B978-0-12-386.... • 3. Andrade C, Rao NS. How antidepressant drugs act: A primer on neuroplasticity as the eventual mediator of antidepressant efficacy. Indian J Psychiatry. 2010 Oct;52(4):378-86. doi: 10.4103/0019-5545.74318. • 4. PubChem [Internet]. Bethesda (MD): National Library of Medicine (US), National Center for Biotechnology Information; 2004-. PubChem Compound Summary for CID 3748, Iproniazid; • 5. PubChem [Internet]. Bethesda (MD): National Library of Medicine (US), National Center for Biotechnology Information; 2004-. PubChem Compound Summary for CID 3696, Imipramine; • 6. Fayez R, Gupta V. Imipramine. [Updated 2023 May 22]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. • 7. PubChem [Internet]. Bethesda (MD): National Library of Medicine (US), National Center for Biotechnology Information; 2004-. PubChem Compound Summary for CID 5202, Serotonin; • 8. PubChem [Internet]. Bethesda (MD): National Library of Medicine (US), National Center for Biotechnology Information; 2004-. PubChem Compound Summary for CID 439260, Norepinephrine; • 9. PubChem [Internet]. Bethesda (MD): National Library of Medicine (US), National Center for Biotechnology Information; 2004-. PubChem Compound Summary for CID 681, Dopamine; • 10. Steven M. Fox, Robin Downing, 14 - Rehabilitating the Painful Patient: Pain Management in Physical Rehabilitation, Editor(s): Darryl Millis, David Levine, Canine Rehabilitation and Physical Therapy (Second Edition), W.B. Saunders, 2014, Pages 243-253, ISBN 9781437703092, • https://doi.org/10.1016/B978-1-4377-0.... • 11. PubChem [Internet]. Bethesda (MD): National Library of Medicine (US), National Center for Biotechnology Information; 2004-. PubChem Compound Summary for CID 3696, Imipramine; [cited 2024 July 9]. Available from: https://pubchem.ncbi.nlm.nih.gov/comp... • 12. Stepanenko YD, Sibarov DA, Shestakova NN, Antonov SM. Tricyclic Antidepressant Structure-Related Alterations in Calcium-Dependent Inhibition and Open-Channel Block of NMDA Receptors. Front Pharmacol. 2022 Feb 14;12:815368. doi: 10.3389/fphar.2021.815368. PMID: 35237149; PMCID: PMC8882908. • 13. P.M. Wax, Monoamine Oxidase Inhibitors, Editor(s): Philip Wexler, Encyclopedia of Toxicology (Third Edition), Academic Press, 2014,mPages 389-390, ISBN 9780123864550, • 14. Obata, Y., Kubota-Sakashita, M., Kasahara, T. et al. Phenethylamine is a substrate of monoamine oxidase B in the paraventricular thalamic nucleus. Sci Rep 12, 17 (2022). https://doi.org/10.1038/s41598-021-03... • 15. J.Gordon Millichap, Michelle M Yee, The diet factor in pediatric and adolescent migraine, Pediatric Neurology, Volume 28, Issue 1, 2003, Pages 9-15, ISSN 0887-8994, • https://doi.org/10.1016/S0887-8994(02.... • 16. Van den Eynde V, Gillman PK, Blackwell BB. The Prescriber's Guide to the MAOI Diet-Thinking Through Tyramine Troubles. Psychopharmacol Bull. 2022 May 31;52(2):73-116. PMID: 35721816; PMCID: PMC9172554. • 17. Gaby Andersen, Patrick Marcinek, Nicole Sulzinger, Peter Schieberle, Dietmar Krautwurst, Food sources and biomolecular targets of tyramine, Nutrition Reviews, Volume 77, Issue 2, February 2019, Pages 107–115, • 18. Coleman JA, Green EM, Gouaux E. X-ray structures and mechanism of the human serotonin transporter. Nature. 2016 Apr 21;532(7599):334-9. doi: 10.1038/nature17629. • 19. Jacquelyn L. Bainbridge, Robert Lee Page, J. Mark Ruscin, Elucidating the Mechanism of Action and Potential Interactions of MAO-B Inhibitors, Neurologic Clinics, Volume 26, Issue 3, Supplement, 2008, Pages 85-96, ISSN 0733-8619
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