Testosterone Production

>> YOUR LINK HERE: ___ http://youtube.com/watch?v=djqqao2Uebo

Developed and produced by http://www.MechanismsinMedicine.com • Animation Description: This animation represents a visual interpretation of the production of testosterone and is not indicative of clinical effectiveness. • The hypothalamus releases gonadotropin-releasing hormone (GnRH) in pulses every 60 to 90 minutes to stimulate the pulsatile release of luteinizing hormone (LH) from the pituitary gland into the bloodstream. • LH binds the LH receptor on the Leydig cells of the testes. • Binding initiates a cascade of events which include the conversion of cholesterol (depicted as LDL here) to pregnenolone followed by a series of reactions, which convert pregnenolone to testosterone. • Testosterone, secreted by the testes, diffuses into the peripheral circulation to be carried to target tissues. • In liver, muscle and adipose tissue, testosterone binds directly to its androgen receptor (AR) to exert its biological effect. • In skin, hair, the prostate gland and gonadal tissue, testosterone must be converted to dihydrotestosterone (DHT) by 5-alpha-reductase in order to bind the androgen receptor. • In bone and brain, testosterone is converted by aromatization to estradiol (E2), which binds the estrogen receptor (E2R) to carry out its effects. • • There is an accompanying accredited online resource, http://www.ManagingTD.ca that contains the learning materials, as well as videos, animations an interactive algorithm.

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