MetaPalette mSystems

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http://youtube.com/watch?v=emMCAJ2oeP4

Taxonomic profiling is a challenging first step when analyzing a metagenomic sample. This work presents a method that facilitates fine-scale characterization of the presence, abundance, and evolutionary relatedness of organisms present in a given sample but absent from the training database. We calculate a “𝘬-mer palette” which summarizes the information from all reads, not just those in conserved genes or containing taxon-specific markers. The compositions of palettes are easy to model, allowing rapid inference of community composition. In addition to providing strain-level information where applicable, our approach provides taxonomic profiles that are more accurate than those of competing methods. • MetaPalette: a k-mer Painting Approach for Metagenomic Taxonomic Profiling and Quantification of Novel Strain Variation • David Koslicki, Daniel Falush • Janet K. Jansson, Editor • Published in mSystems on 07 June 2016 • Direct link: http://msystems.asm.org/content/1/3/e... • mSystems™ publishes preeminent work that stems from applying technologies for high-throughput analyses to achieve insights into the metabolic and regulatory systems at the scale of both the single cell and microbial communities. The scope of mSystems™ encompasses all important biological and biochemical findings drawn from analyses of large data sets, as well as new computational approaches for deriving these insights. mSystems™ welcomes submissions from researchers who focus on the microbiome, genomics, metagenomics, transcriptomics, metabolomics, proteomics, glycomics, bioinformatics, and computational microbiology. mSystems™ provides streamlined decisions, while carrying on ASM's tradition of rigorous peer review. • ________________________________________________ • Subscribe to ASM's YouTube channel at https://goo.gl/mOVHlK • Learn more about the American Society for Microbiology at http://www.asm.org • Become a member today at http://www.asmscience.org/join • Interact with us on social at: • Facebook • Show your support and get updates on the latest microbial offerings and news from the ASM. • / asmfan • ASM International Facebook Groups • Join an ASM International Facebook Group and connect with microbiologists in your region. • http://www.asm.org/index.php/programs... • Twitter • Follow all the latest news from the Society. • / asmicrobiology • Instagram • Outstanding images of your favorite viruses, fungi, bacteria and parasites • / asmicrobiology

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