Altogen Biosystems In Vitro Keratinocyte Transfection Tutorial

>> YOUR LINK HERE: ___ http://youtube.com/watch?v=fDhgDsgBOr4

Keratinocyte Cell Line: • Keratinocytes, which comprise ~95% of the epidermis, are the most abundant of skin cells. Originating in the basal skin layer, keratinocytes grow densely and move outward through the epidermis layers until they are continuously shed and replaced. Keratinocytes are responsible for producing keratin the primary nail and hair component. Keratinocytes grow as tightly interwoven cells that form seams between nerves and tissues underlying the epidermis, effectively maintaining a protective barrier against foreign substances that would invade through the skin. Keratinocytes are additionally critical for wound healing. They demonstrate a high expression of PDGF A (fibroblast stimulating platelet-derived growth factor), effectively regulating fibroblast activity, as well as high expression of epidermal proinflammatory cytokine IL-1. Bcl-2 overexpression has been demonstrated to protect keratinocytes from Ukrain-induced apoptosis. Keratinocytes are popularly used to develop in vitro skin irritant assessment techniques as well as other biomedical research applications revolving around skin. Altogen Biosystems developed a proprietary lipid-based keratinocyte-specific transfection kit formulated for max efficiency which has been verified by Western blots and qRT-PCR. • https://altogen.com/product/keratinoc...

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