Deltacron

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Is deltacron a new mutation with the transmissibility of omicron and the pathogenesis of delta? • https://www.telegraph.co.uk/news/2022... • Cyprus • Not a new form of coronavirus • Recombination event • Lab contamination • Prof Leondios Kostrikis, professor of biological sciences,University of Cyprus, Head of the Laboratory of Biotechnology and Molecular Virology • Suggested delta and omicron variants had amalgamated • There are currently omicron and delta co-infections and we found this strain that is a combination of these two • 25 sequences were subsequently submitted to GISAID • https://www.gisaid.org • Dr Thomas Peacock, Imperial College London, Department of Infectious Disease • November, very small cluster, • really awful spike mutation profile • B.1.1.529, later omicron • Deltacron genetic profile • Looks to be quite clearly contamination • Several colleagues • almost definitely contamination • doesn’t look like a real recombinant • Dr Simon Clarke, University of Reading • It’s perfectly possible for different versions of the virus that causes Covid-19 to combine sections of their genetic material, • creating a recombinant, • which is a genetic mosaic of the different variants • with altered characteristics, • but they contain a number of telltale signs • and ‘deltacron’ just doesn’t have any • Instead, its proposed genetic code looks more like what would happen if you contaminated one sample with another • That could have happened at any point between sampling and sequencing in the laboratory • and I strongly suspect this is what has happened. • New variants will continue to come along, but I don’t think this is one. • Deltacron’s genetic code • Scars of a notoriously faulty primer • V3 72 amplicon • As of Monday morning • https://www.gov.uk/government/publica... • https://www.gov.uk/government/news/co... • UKHSA no new variants under surveillance • Prof Leondios Kostrikis • https://www.scmp.com/news/world/europ... • indicate an evolutionary pressure to an ancestral strain to acquire these mutations and not a result of a single recombination event • Deltacron infection is higher among patients hospitalised for Covid-19 than among non-hospitalised patients, • so that rules out the contamination hypothesis • • the samples were processed in multiple sequencing procedures in more than one country. • And at least one sequence from Israel deposited in a global database exhibits genetic characteristics of Deltacron • Professor Nick Loman, microbial genomics professor University of Birmingham (UK) • While a recombinant form of Delta and Omicron would not be a complete surprise, • the finding from Cyprus is more likely a “technical artefact” that arose in the process of sequencing the viral genome

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