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#NeuromuscularJunction #SynapticCleft #MyastheniaGravis • Neuromuscular Junction | Structure , Function Diseases🩺 • Like this video? • Sign up now on our website at https://www.DrNajeebLectures.com to access 800+ Exclusive videos on Basic Medical Sciences Clinical Medicine. These are premium videos (NOT FROM YOUTUBE). All these videos come with English subtitles download options. Sign up now! Get Lifetime Access for a one-time payment of $99 ONLY! • Sign up now on our website at https://members.drnajeeblectures.com/ • --------------------------------------------------------------------------------------------------------------------------- • Why sign up for premium membership? Here's why! • Membership Features for premium website members. • 1. More than 800+ Medical Lectures. • 2. Basic Medical Sciences Clinical Medicine. • 3. Mobile-friendly interface with android and iOS apps. • 4. English subtitles and new videos every week. • 5. Download option for offline video playback. • 6. Fanatic customer support and that's 24/7. • 7. Fast video playback option to learn faster. • 8. Trusted by over 2M+ students in 190 countries. • --------------------------------------------------------------------------------------------------------------------------- • ▬▬▬▬▬▬▬▬▬▬ Contents of this video ▬▬▬▬▬▬▬▬▬▬ • 00:00:00 Neuromuscular Transmission release of chemical neurotransmitter in Motor End Plate. • Conversion of Chemical message into Electrical message. • Neuro Muscular Junction (NMJ); defining location. • How the motor neurons talk to the muscles • 00:06:27 Neurotransmitters (NTs); their storage in Motor Nerve Ending (MNE). • Post-Synaptic membrane; definition of synapse. • Neuro Muscular Junction (NMJ); role as chemical synapses . • Pre- and Post-Synaptic membrane; Pre synaptic membrane will talk and post-synaptic will listen . • A one-way transmission not two-way; since only in one direction. • • 00:09:26 Acetylcholine (ACh); storage in vesicles. • Synthesis of Vesicles in Cell Body of neurons in the Spinal Cord; proteins as a principle only synthesized in neuronal cell bodies. • ACh synthesized in the Nerve Ending; Nerve Ending as a “semi-autonomous” unit; capable of NT synthesis. • • 00:16:14 Synthesis of Ach in detail; role of “Choline transporters”, Acetyl CoA Choline Acetyl Transferase (CAT) enzyme. • Storage concentration of of ACh in vesicles; stored as “chemical signaling molecules”. • 00:21:53 1-Action Potential; its mechanism of generation role of voltage-gated Na-channels; Na influx • 2-Ca+ channels; role of “Ca-sensitive proteins” • 3-Fusion of Vesicular membrane with pre-synaptic membrane triggered as a result of Ca influx; Ach release into the SYNAPTIC CLEFT; Exocytosis of Neurotransmitter. • SYNAPTOBREVIN SYNTEXIN; role in Ach release. • Classification of above 3 as steps of PRE-SYNAPTIC EVENTS on NM Junction. • • 00:30:40 Movement of Ach from Pre-synaptic Membrane to Post-Synaptic Membrane (SYNAPTIC CLEFT) through diffusion. • ACh sensitive Receptors/channels on post-synaptic membrane; their role as “ears of the muscles”. • NICOTINIC CHOLINERGIC channels (NCC); Resting Membrane Potential (RMP) importance of heavy Na+ influx in depolarization of post-synaptic membrane. • • 00:41:37 MOTOR-END PLATE (MEP) POTENTIAL Miniature End Plate Potential concept. • MEP potential Action Potential compared. Depolarization spreading to flanks of post-synaptic membrane. • Action Potential triggering in Voltage-gated Na+ channels in the flanks. • Reaching of Threshold Potential spreading of wave of depolarization. • 00:49:20 Revision of basic concept of NM Transmission at NMJ. Talking of neurons completed. • 00:53:36 ACETYL-CHOLINESTERASES; their role in breaking of Ach; termination of its action. • 00:58:50 CLATHRINS proteins; vesicle formation role in recycling of choline. • • 01:01:15 MYASTHENIA GRAVIS: Autoantibodies attaching to Nicotinic Cholinergic Receptors (NCR) at NMJ. • NEUROMUSCULAR TRANSMISSION BLOCKADE due to Anti-cholinergic antibodies attaching at Nicotinic Cholinergic Receptors. • TREATMENT: Acetylcholinesterase inhibitor/blocker (AchI) resulting in increased no of Ach in NMJ. • Physostigmine, Neostigmine • 01:09:11 EATON LAMBART MYASTHENIC SYNDROME; autoimmune disease; works by blocking Ca+ channels on pre-synaptic NMJ. • Differentiating b/w Myasthenia Eaton Lambert: Weakness and/or difficulty in initiating movement in both. • --------------------------------------------------------------------------------------------------------------------------- • Join this channel to get access to perks: • Sign up now on our website at https://members.drnajeeblectures.com/... • / @doctornajeeb • Follow us on Facebook :- / drnajeeb • Follow us on Instagram :- / drnajeeblectures
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